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Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla prot...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780346/ https://www.ncbi.nlm.nih.gov/pubmed/35057443 http://dx.doi.org/10.3390/nu14020262 |
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author | Stępień, Anna Koziarska-Rościszewska, Małgorzata Rysz, Jacek Stępień, Mariusz |
author_facet | Stępień, Anna Koziarska-Rościszewska, Małgorzata Rysz, Jacek Stępień, Mariusz |
author_sort | Stępień, Anna |
collection | PubMed |
description | Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla protein (MGP) is VK-dependent. Chronic kidney disease (CKD) patients, both non-dialysed and hemodialysed, often have VK deficiency. Elevated uncarboxylated matrix Gla protein (ucMGP) levels indirectly reflected VK deficiency and are associated with a higher risk of cardiovascular events in these patients. It has been suggested that VK intake may reduce the VC and related cardiovascular risk. Vitamin K intake has been suggested to reduce VC and the associated cardiovascular risk. The role and possibility of VK supplementation as well as the impact of anticoagulation therapy on VK deficiency in CKD patients is discussed. |
format | Online Article Text |
id | pubmed-8780346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87803462022-01-22 Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects Stępień, Anna Koziarska-Rościszewska, Małgorzata Rysz, Jacek Stępień, Mariusz Nutrients Review Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla protein (MGP) is VK-dependent. Chronic kidney disease (CKD) patients, both non-dialysed and hemodialysed, often have VK deficiency. Elevated uncarboxylated matrix Gla protein (ucMGP) levels indirectly reflected VK deficiency and are associated with a higher risk of cardiovascular events in these patients. It has been suggested that VK intake may reduce the VC and related cardiovascular risk. Vitamin K intake has been suggested to reduce VC and the associated cardiovascular risk. The role and possibility of VK supplementation as well as the impact of anticoagulation therapy on VK deficiency in CKD patients is discussed. MDPI 2022-01-08 /pmc/articles/PMC8780346/ /pubmed/35057443 http://dx.doi.org/10.3390/nu14020262 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stępień, Anna Koziarska-Rościszewska, Małgorzata Rysz, Jacek Stępień, Mariusz Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title | Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title_full | Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title_fullStr | Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title_full_unstemmed | Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title_short | Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects |
title_sort | biological role of vitamin k—with particular emphasis on cardiovascular and renal aspects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780346/ https://www.ncbi.nlm.nih.gov/pubmed/35057443 http://dx.doi.org/10.3390/nu14020262 |
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