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Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects

Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla prot...

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Autores principales: Stępień, Anna, Koziarska-Rościszewska, Małgorzata, Rysz, Jacek, Stępień, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780346/
https://www.ncbi.nlm.nih.gov/pubmed/35057443
http://dx.doi.org/10.3390/nu14020262
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author Stępień, Anna
Koziarska-Rościszewska, Małgorzata
Rysz, Jacek
Stępień, Mariusz
author_facet Stępień, Anna
Koziarska-Rościszewska, Małgorzata
Rysz, Jacek
Stępień, Mariusz
author_sort Stępień, Anna
collection PubMed
description Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla protein (MGP) is VK-dependent. Chronic kidney disease (CKD) patients, both non-dialysed and hemodialysed, often have VK deficiency. Elevated uncarboxylated matrix Gla protein (ucMGP) levels indirectly reflected VK deficiency and are associated with a higher risk of cardiovascular events in these patients. It has been suggested that VK intake may reduce the VC and related cardiovascular risk. Vitamin K intake has been suggested to reduce VC and the associated cardiovascular risk. The role and possibility of VK supplementation as well as the impact of anticoagulation therapy on VK deficiency in CKD patients is discussed.
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spelling pubmed-87803462022-01-22 Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects Stępień, Anna Koziarska-Rościszewska, Małgorzata Rysz, Jacek Stępień, Mariusz Nutrients Review Vitamin K (VK) plays many important functions in the body. The most important of them include the contribution in calcium homeostasis and anticoagulation. Vascular calcification (VC) is one of the most important mechanisms of renal pathology. The most potent inhibitor of this process—matrix Gla protein (MGP) is VK-dependent. Chronic kidney disease (CKD) patients, both non-dialysed and hemodialysed, often have VK deficiency. Elevated uncarboxylated matrix Gla protein (ucMGP) levels indirectly reflected VK deficiency and are associated with a higher risk of cardiovascular events in these patients. It has been suggested that VK intake may reduce the VC and related cardiovascular risk. Vitamin K intake has been suggested to reduce VC and the associated cardiovascular risk. The role and possibility of VK supplementation as well as the impact of anticoagulation therapy on VK deficiency in CKD patients is discussed. MDPI 2022-01-08 /pmc/articles/PMC8780346/ /pubmed/35057443 http://dx.doi.org/10.3390/nu14020262 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stępień, Anna
Koziarska-Rościszewska, Małgorzata
Rysz, Jacek
Stępień, Mariusz
Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title_full Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title_fullStr Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title_full_unstemmed Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title_short Biological Role of Vitamin K—With Particular Emphasis on Cardiovascular and Renal Aspects
title_sort biological role of vitamin k—with particular emphasis on cardiovascular and renal aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780346/
https://www.ncbi.nlm.nih.gov/pubmed/35057443
http://dx.doi.org/10.3390/nu14020262
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