Cargando…

Naloxegol and Postoperative Urinary Retention: A Randomized Trial

Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given...

Descripción completa

Detalles Bibliográficos
Autores principales: Turan, Alparslan, Fang, Jonathan, Esa, Wael Ali Sakr, Hamadnalla, Hassan, Leung, Steve, Pu, Xuan, Raza, Syed, Chelnick, David, Mounir Soliman, Loran, Seif, John, Ruetzler, Kurt, Sessler, Daniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780376/
https://www.ncbi.nlm.nih.gov/pubmed/35054148
http://dx.doi.org/10.3390/jcm11020454
_version_ 1784637822845583360
author Turan, Alparslan
Fang, Jonathan
Esa, Wael Ali Sakr
Hamadnalla, Hassan
Leung, Steve
Pu, Xuan
Raza, Syed
Chelnick, David
Mounir Soliman, Loran
Seif, John
Ruetzler, Kurt
Sessler, Daniel I.
author_facet Turan, Alparslan
Fang, Jonathan
Esa, Wael Ali Sakr
Hamadnalla, Hassan
Leung, Steve
Pu, Xuan
Raza, Syed
Chelnick, David
Mounir Soliman, Loran
Seif, John
Ruetzler, Kurt
Sessler, Daniel I.
author_sort Turan, Alparslan
collection PubMed
description Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given placebo. Methods: 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. Results: 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), p = 0.84. There were no significant differences in ORSDS or QoR. There were 19 (29%) patients assigned to naloxegol who needed indwelling urination catheterization versus 7 (11%) patients in the placebo group, p = 0.012. Conclusions: Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery.
format Online
Article
Text
id pubmed-8780376
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87803762022-01-22 Naloxegol and Postoperative Urinary Retention: A Randomized Trial Turan, Alparslan Fang, Jonathan Esa, Wael Ali Sakr Hamadnalla, Hassan Leung, Steve Pu, Xuan Raza, Syed Chelnick, David Mounir Soliman, Loran Seif, John Ruetzler, Kurt Sessler, Daniel I. J Clin Med Article Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given placebo. Methods: 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. Results: 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), p = 0.84. There were no significant differences in ORSDS or QoR. There were 19 (29%) patients assigned to naloxegol who needed indwelling urination catheterization versus 7 (11%) patients in the placebo group, p = 0.012. Conclusions: Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery. MDPI 2022-01-17 /pmc/articles/PMC8780376/ /pubmed/35054148 http://dx.doi.org/10.3390/jcm11020454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turan, Alparslan
Fang, Jonathan
Esa, Wael Ali Sakr
Hamadnalla, Hassan
Leung, Steve
Pu, Xuan
Raza, Syed
Chelnick, David
Mounir Soliman, Loran
Seif, John
Ruetzler, Kurt
Sessler, Daniel I.
Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title_full Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title_fullStr Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title_full_unstemmed Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title_short Naloxegol and Postoperative Urinary Retention: A Randomized Trial
title_sort naloxegol and postoperative urinary retention: a randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780376/
https://www.ncbi.nlm.nih.gov/pubmed/35054148
http://dx.doi.org/10.3390/jcm11020454
work_keys_str_mv AT turanalparslan naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT fangjonathan naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT esawaelalisakr naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT hamadnallahassan naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT leungsteve naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT puxuan naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT razasyed naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT chelnickdavid naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT mounirsolimanloran naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT seifjohn naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT ruetzlerkurt naloxegolandpostoperativeurinaryretentionarandomizedtrial
AT sesslerdanieli naloxegolandpostoperativeurinaryretentionarandomizedtrial