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Naloxegol and Postoperative Urinary Retention: A Randomized Trial
Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780376/ https://www.ncbi.nlm.nih.gov/pubmed/35054148 http://dx.doi.org/10.3390/jcm11020454 |
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author | Turan, Alparslan Fang, Jonathan Esa, Wael Ali Sakr Hamadnalla, Hassan Leung, Steve Pu, Xuan Raza, Syed Chelnick, David Mounir Soliman, Loran Seif, John Ruetzler, Kurt Sessler, Daniel I. |
author_facet | Turan, Alparslan Fang, Jonathan Esa, Wael Ali Sakr Hamadnalla, Hassan Leung, Steve Pu, Xuan Raza, Syed Chelnick, David Mounir Soliman, Loran Seif, John Ruetzler, Kurt Sessler, Daniel I. |
author_sort | Turan, Alparslan |
collection | PubMed |
description | Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given placebo. Methods: 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. Results: 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), p = 0.84. There were no significant differences in ORSDS or QoR. There were 19 (29%) patients assigned to naloxegol who needed indwelling urination catheterization versus 7 (11%) patients in the placebo group, p = 0.012. Conclusions: Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery. |
format | Online Article Text |
id | pubmed-8780376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87803762022-01-22 Naloxegol and Postoperative Urinary Retention: A Randomized Trial Turan, Alparslan Fang, Jonathan Esa, Wael Ali Sakr Hamadnalla, Hassan Leung, Steve Pu, Xuan Raza, Syed Chelnick, David Mounir Soliman, Loran Seif, John Ruetzler, Kurt Sessler, Daniel I. J Clin Med Article Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given placebo. Methods: 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. Results: 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), p = 0.84. There were no significant differences in ORSDS or QoR. There were 19 (29%) patients assigned to naloxegol who needed indwelling urination catheterization versus 7 (11%) patients in the placebo group, p = 0.012. Conclusions: Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery. MDPI 2022-01-17 /pmc/articles/PMC8780376/ /pubmed/35054148 http://dx.doi.org/10.3390/jcm11020454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Turan, Alparslan Fang, Jonathan Esa, Wael Ali Sakr Hamadnalla, Hassan Leung, Steve Pu, Xuan Raza, Syed Chelnick, David Mounir Soliman, Loran Seif, John Ruetzler, Kurt Sessler, Daniel I. Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title | Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title_full | Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title_fullStr | Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title_full_unstemmed | Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title_short | Naloxegol and Postoperative Urinary Retention: A Randomized Trial |
title_sort | naloxegol and postoperative urinary retention: a randomized trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780376/ https://www.ncbi.nlm.nih.gov/pubmed/35054148 http://dx.doi.org/10.3390/jcm11020454 |
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