Cargando…
Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia
This observational study aimed at investigating pain in stroke patients with upper limb spastic dystonia. Forty-one consecutive patients were enrolled. A 0–10 numeric rating scale was used to evaluate pain at rest and during muscle tone assessment. Patients were asked to indicate the most painful jo...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780435/ https://www.ncbi.nlm.nih.gov/pubmed/35051017 http://dx.doi.org/10.3390/toxins14010039 |
_version_ | 1784637837339000832 |
---|---|
author | Trompetto, Carlo Marinelli, Lucio Mori, Laura Puce, Luca Avanti, Chiara Saretti, Elena Biasotti, Giulia Amella, Roberta Cotellessa, Filippo Restivo, Domenico A. Currà, Antonio |
author_facet | Trompetto, Carlo Marinelli, Lucio Mori, Laura Puce, Luca Avanti, Chiara Saretti, Elena Biasotti, Giulia Amella, Roberta Cotellessa, Filippo Restivo, Domenico A. Currà, Antonio |
author_sort | Trompetto, Carlo |
collection | PubMed |
description | This observational study aimed at investigating pain in stroke patients with upper limb spastic dystonia. Forty-one consecutive patients were enrolled. A 0–10 numeric rating scale was used to evaluate pain at rest and during muscle tone assessment. Patients were asked to indicate the most painful joint at passive mobilization (shoulder, elbow, wrist-fingers). The DN4 questionnaire was administered to disclose neuropathic pain. All patients were assessed just before and 1 month after incobotulinumtoxin-A treatment. Pain was present in 22 patients, worsened or triggered by passive muscle stretching. DN4 scored < 4 in 20 patients. The most painful joints were wrist–fingers in 12 patients, elbow in 5 patients and shoulder in the remaining 5 patients. Both elbow and wrist–fingers pain correlated with muscle tone. BoNT-A treatment reduced pain in all the joints, including the shoulder. We discussed that nociceptive pain is present in a vast proportion of patients with upper limb spastic dystonia. BoNT-A treatment reduced both spastic dystonia and pain in all the joints but the shoulder, where the effect on pain could be mediated by the reduction of pathological postures involving the other joints. |
format | Online Article Text |
id | pubmed-8780435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87804352022-01-22 Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia Trompetto, Carlo Marinelli, Lucio Mori, Laura Puce, Luca Avanti, Chiara Saretti, Elena Biasotti, Giulia Amella, Roberta Cotellessa, Filippo Restivo, Domenico A. Currà, Antonio Toxins (Basel) Article This observational study aimed at investigating pain in stroke patients with upper limb spastic dystonia. Forty-one consecutive patients were enrolled. A 0–10 numeric rating scale was used to evaluate pain at rest and during muscle tone assessment. Patients were asked to indicate the most painful joint at passive mobilization (shoulder, elbow, wrist-fingers). The DN4 questionnaire was administered to disclose neuropathic pain. All patients were assessed just before and 1 month after incobotulinumtoxin-A treatment. Pain was present in 22 patients, worsened or triggered by passive muscle stretching. DN4 scored < 4 in 20 patients. The most painful joints were wrist–fingers in 12 patients, elbow in 5 patients and shoulder in the remaining 5 patients. Both elbow and wrist–fingers pain correlated with muscle tone. BoNT-A treatment reduced pain in all the joints, including the shoulder. We discussed that nociceptive pain is present in a vast proportion of patients with upper limb spastic dystonia. BoNT-A treatment reduced both spastic dystonia and pain in all the joints but the shoulder, where the effect on pain could be mediated by the reduction of pathological postures involving the other joints. MDPI 2022-01-05 /pmc/articles/PMC8780435/ /pubmed/35051017 http://dx.doi.org/10.3390/toxins14010039 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trompetto, Carlo Marinelli, Lucio Mori, Laura Puce, Luca Avanti, Chiara Saretti, Elena Biasotti, Giulia Amella, Roberta Cotellessa, Filippo Restivo, Domenico A. Currà, Antonio Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title | Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title_full | Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title_fullStr | Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title_full_unstemmed | Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title_short | Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia |
title_sort | effectiveness of botulinum toxin on pain in stroke patients suffering from upper limb spastic dystonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780435/ https://www.ncbi.nlm.nih.gov/pubmed/35051017 http://dx.doi.org/10.3390/toxins14010039 |
work_keys_str_mv | AT trompettocarlo effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT marinellilucio effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT morilaura effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT puceluca effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT avantichiara effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT sarettielena effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT biasottigiulia effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT amellaroberta effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT cotellessafilippo effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT restivodomenicoa effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia AT curraantonio effectivenessofbotulinumtoxinonpaininstrokepatientssufferingfromupperlimbspasticdystonia |