A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic

A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as...

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Detalles Bibliográficos
Autores principales: Guo, Xin, Liu, Chang-Xiang, Lu, Yuan, Wang, Ya-Wen, Peng, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780492/
https://www.ncbi.nlm.nih.gov/pubmed/35056803
http://dx.doi.org/10.3390/molecules27020489
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author Guo, Xin
Liu, Chang-Xiang
Lu, Yuan
Wang, Ya-Wen
Peng, Yu
author_facet Guo, Xin
Liu, Chang-Xiang
Lu, Yuan
Wang, Ya-Wen
Peng, Yu
author_sort Guo, Xin
collection PubMed
description A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by (1)H NMR, MS and DFT calculation. Moreover, SWJT-4 could be used as a fluorescent test paper to detect DCP vapor.
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spelling pubmed-87804922022-01-22 A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic Guo, Xin Liu, Chang-Xiang Lu, Yuan Wang, Ya-Wen Peng, Yu Molecules Article A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by (1)H NMR, MS and DFT calculation. Moreover, SWJT-4 could be used as a fluorescent test paper to detect DCP vapor. MDPI 2022-01-13 /pmc/articles/PMC8780492/ /pubmed/35056803 http://dx.doi.org/10.3390/molecules27020489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Xin
Liu, Chang-Xiang
Lu, Yuan
Wang, Ya-Wen
Peng, Yu
A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title_full A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title_fullStr A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title_full_unstemmed A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title_short A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic
title_sort double-site chemodosimeter for selective fluorescence detection of a nerve agent mimic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780492/
https://www.ncbi.nlm.nih.gov/pubmed/35056803
http://dx.doi.org/10.3390/molecules27020489
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