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Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling
Reliable mathematical models are important tools for design/optimization of haemo-filtration modules. For a specific module, such a model requires knowledge of fluid- mechanical and mass transfer parameters, which have to be determined through experimental data representative of the usual countercur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780501/ https://www.ncbi.nlm.nih.gov/pubmed/35054588 http://dx.doi.org/10.3390/membranes12010062 |
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author | Moschona, Alexandra Kostoglou, Margaritis Karabelas, Anastasios J. |
author_facet | Moschona, Alexandra Kostoglou, Margaritis Karabelas, Anastasios J. |
author_sort | Moschona, Alexandra |
collection | PubMed |
description | Reliable mathematical models are important tools for design/optimization of haemo-filtration modules. For a specific module, such a model requires knowledge of fluid- mechanical and mass transfer parameters, which have to be determined through experimental data representative of the usual countercurrent operation. Attempting to determine all these parameters, through measured/external flow-rates and pressures, combined with the inherent inaccuracies of pressure measurements, creates an ill-posed problem (as recently shown). The novel systematic methodology followed herein, demonstrated for Newtonian fluids, involves specially designed experiments, allowing first the independent reliable determination of fluid-mechanical parameters. In this paper, the method is further developed, to determine the complete mass transfer module-characteristics; i.e., the mass transfer problem is modelled/solved, employing the already fully-described flow field. Furthermore, the model is validated using new/detailed experimental data on concentration profiles of a typical solute (urea) in counter-current flow. A single intrinsic-parameter value (i.e., the unknown effective solute-diffusivity in the membrane) satisfactorily fits all data. Significant insights are also obtained regarding the relative contributions of convective and diffusive mass-transfer. This study completes the method for reliable module simulation in Newtonian-liquid flow and provides the basis for extension to plasma/blood haemofiltration, where account should be also taken of oncotic-pressure and membrane-fouling effects. |
format | Online Article Text |
id | pubmed-8780501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87805012022-01-22 Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling Moschona, Alexandra Kostoglou, Margaritis Karabelas, Anastasios J. Membranes (Basel) Article Reliable mathematical models are important tools for design/optimization of haemo-filtration modules. For a specific module, such a model requires knowledge of fluid- mechanical and mass transfer parameters, which have to be determined through experimental data representative of the usual countercurrent operation. Attempting to determine all these parameters, through measured/external flow-rates and pressures, combined with the inherent inaccuracies of pressure measurements, creates an ill-posed problem (as recently shown). The novel systematic methodology followed herein, demonstrated for Newtonian fluids, involves specially designed experiments, allowing first the independent reliable determination of fluid-mechanical parameters. In this paper, the method is further developed, to determine the complete mass transfer module-characteristics; i.e., the mass transfer problem is modelled/solved, employing the already fully-described flow field. Furthermore, the model is validated using new/detailed experimental data on concentration profiles of a typical solute (urea) in counter-current flow. A single intrinsic-parameter value (i.e., the unknown effective solute-diffusivity in the membrane) satisfactorily fits all data. Significant insights are also obtained regarding the relative contributions of convective and diffusive mass-transfer. This study completes the method for reliable module simulation in Newtonian-liquid flow and provides the basis for extension to plasma/blood haemofiltration, where account should be also taken of oncotic-pressure and membrane-fouling effects. MDPI 2022-01-01 /pmc/articles/PMC8780501/ /pubmed/35054588 http://dx.doi.org/10.3390/membranes12010062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moschona, Alexandra Kostoglou, Margaritis Karabelas, Anastasios J. Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title | Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title_full | Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title_fullStr | Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title_full_unstemmed | Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title_short | Mass Transfer Characteristics of Haemofiltration Modules—Experiments and Modeling |
title_sort | mass transfer characteristics of haemofiltration modules—experiments and modeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780501/ https://www.ncbi.nlm.nih.gov/pubmed/35054588 http://dx.doi.org/10.3390/membranes12010062 |
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