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The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo. Our in vitro experiments identified PA-G as an inhibitor of N-methyl-D-aspartate receptors and a potentiator of γ-aminobutyric ac...
Autores principales: | Kudova, Eva, Mares, Pavel, Hill, Martin, Vondrakova, Katerina, Tsenov, Grygoriy, Chodounska, Hana, Kubova, Hana, Vales, Karel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780580/ https://www.ncbi.nlm.nih.gov/pubmed/35056106 http://dx.doi.org/10.3390/ph15010049 |
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