Cargando…

Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Xin, Yang, Kailin, Li, Renliang, Li, Maomao, Zuo, Jing, Zheng, Bohao, Wang, Wei, Wang, Ping, Zhou, Shengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780708/
https://www.ncbi.nlm.nih.gov/pubmed/35062950
http://dx.doi.org/10.1186/s12943-021-01486-5
Descripción
Sumario:Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While the metabolic hallmarks of cancer have been extensively studied, the metabolic states of the immune cells are less well elucidated. Here we review the metabolic disturbance and fitness of the immune system in the tumor microenvironment (TME), focusing on the impact of oncometabolites to the function of immune cells and the clinical significance of targeting metabolism in anti-tumor immunotherapy. Metabolic alterations in the immune system of TME offer novel therapeutic insight into cancer treatment.