Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While...

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Autores principales: Lian, Xin, Yang, Kailin, Li, Renliang, Li, Maomao, Zuo, Jing, Zheng, Bohao, Wang, Wei, Wang, Ping, Zhou, Shengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780708/
https://www.ncbi.nlm.nih.gov/pubmed/35062950
http://dx.doi.org/10.1186/s12943-021-01486-5
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author Lian, Xin
Yang, Kailin
Li, Renliang
Li, Maomao
Zuo, Jing
Zheng, Bohao
Wang, Wei
Wang, Ping
Zhou, Shengtao
author_facet Lian, Xin
Yang, Kailin
Li, Renliang
Li, Maomao
Zuo, Jing
Zheng, Bohao
Wang, Wei
Wang, Ping
Zhou, Shengtao
author_sort Lian, Xin
collection PubMed
description Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While the metabolic hallmarks of cancer have been extensively studied, the metabolic states of the immune cells are less well elucidated. Here we review the metabolic disturbance and fitness of the immune system in the tumor microenvironment (TME), focusing on the impact of oncometabolites to the function of immune cells and the clinical significance of targeting metabolism in anti-tumor immunotherapy. Metabolic alterations in the immune system of TME offer novel therapeutic insight into cancer treatment.
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spelling pubmed-87807082022-01-21 Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy Lian, Xin Yang, Kailin Li, Renliang Li, Maomao Zuo, Jing Zheng, Bohao Wang, Wei Wang, Ping Zhou, Shengtao Mol Cancer Review Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While the metabolic hallmarks of cancer have been extensively studied, the metabolic states of the immune cells are less well elucidated. Here we review the metabolic disturbance and fitness of the immune system in the tumor microenvironment (TME), focusing on the impact of oncometabolites to the function of immune cells and the clinical significance of targeting metabolism in anti-tumor immunotherapy. Metabolic alterations in the immune system of TME offer novel therapeutic insight into cancer treatment. BioMed Central 2022-01-21 /pmc/articles/PMC8780708/ /pubmed/35062950 http://dx.doi.org/10.1186/s12943-021-01486-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lian, Xin
Yang, Kailin
Li, Renliang
Li, Maomao
Zuo, Jing
Zheng, Bohao
Wang, Wei
Wang, Ping
Zhou, Shengtao
Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title_full Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title_fullStr Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title_full_unstemmed Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title_short Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
title_sort immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780708/
https://www.ncbi.nlm.nih.gov/pubmed/35062950
http://dx.doi.org/10.1186/s12943-021-01486-5
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