Cargando…
Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis
Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphang...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780734/ https://www.ncbi.nlm.nih.gov/pubmed/35056769 http://dx.doi.org/10.3390/molecules27020454 |
_version_ | 1784637917136683008 |
---|---|
author | Kim, Hyoung Moon Oh, Seyeon Byun, Kyung-A Yang, Jin Young Sun, Hye Jin Kang, Donghwan Son, Kuk Hui Byun, Kyunghee |
author_facet | Kim, Hyoung Moon Oh, Seyeon Byun, Kyung-A Yang, Jin Young Sun, Hye Jin Kang, Donghwan Son, Kuk Hui Byun, Kyunghee |
author_sort | Kim, Hyoung Moon |
collection | PubMed |
description | Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphangiogenesis by activating the BRAF/MEK/ERK pathway and decreasing tyrosinase activity, in the UV-B exposed animal model. The HSP90/BRAF/MEK/ERK pathway was upregulated by RF. Tyrosinase activity and the VEGF-C/VEGFR 3/PI3K/pAKT1/2/pERK1/2 pathway, which increase lymphangiogenesis, as well as the expression of the lymphatic endothelial marker LYVE-1, were increased by RF. Additionally, the number of melanin-containing dermal macrophages, the melanin content in the lymph nodes, and melanin deposition in the skin were decreased by RF. In conclusion, RF increased HSP90/BRAF/MEK/ERK expression, which decreased tyrosinase activity and increased lymphangiogenesis to eventually promote the clearance of dermal melanin-containing macrophages, thereby decreasing skin pigmentation. |
format | Online Article Text |
id | pubmed-8780734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87807342022-01-22 Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis Kim, Hyoung Moon Oh, Seyeon Byun, Kyung-A Yang, Jin Young Sun, Hye Jin Kang, Donghwan Son, Kuk Hui Byun, Kyunghee Molecules Article Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphangiogenesis by activating the BRAF/MEK/ERK pathway and decreasing tyrosinase activity, in the UV-B exposed animal model. The HSP90/BRAF/MEK/ERK pathway was upregulated by RF. Tyrosinase activity and the VEGF-C/VEGFR 3/PI3K/pAKT1/2/pERK1/2 pathway, which increase lymphangiogenesis, as well as the expression of the lymphatic endothelial marker LYVE-1, were increased by RF. Additionally, the number of melanin-containing dermal macrophages, the melanin content in the lymph nodes, and melanin deposition in the skin were decreased by RF. In conclusion, RF increased HSP90/BRAF/MEK/ERK expression, which decreased tyrosinase activity and increased lymphangiogenesis to eventually promote the clearance of dermal melanin-containing macrophages, thereby decreasing skin pigmentation. MDPI 2022-01-11 /pmc/articles/PMC8780734/ /pubmed/35056769 http://dx.doi.org/10.3390/molecules27020454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Hyoung Moon Oh, Seyeon Byun, Kyung-A Yang, Jin Young Sun, Hye Jin Kang, Donghwan Son, Kuk Hui Byun, Kyunghee Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title | Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title_full | Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title_fullStr | Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title_full_unstemmed | Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title_short | Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis |
title_sort | radiofrequency irradiation mitigated uv-b-induced skin pigmentation by increasing lymphangiogenesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780734/ https://www.ncbi.nlm.nih.gov/pubmed/35056769 http://dx.doi.org/10.3390/molecules27020454 |
work_keys_str_mv | AT kimhyoungmoon radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT ohseyeon radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT byunkyunga radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT yangjinyoung radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT sunhyejin radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT kangdonghwan radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT sonkukhui radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis AT byunkyunghee radiofrequencyirradiationmitigateduvbinducedskinpigmentationbyincreasinglymphangiogenesis |