Cargando…

Mirogabalin Decreases Pain-like Behaviours and Improves Opioid and Ketamine Antinociception in a Mouse Model of Neuropathic Pain

Neuropathic pain remains a difficult clinical challenge due to its diverse aetiology and complex pathomechanisms, which are yet to be fully understood. Despite the variety of available therapies, many patients suffer from ineffective pain relief; hence, the search for more efficacious treatments con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zajączkowska, Renata, Rojewska, Ewelina, Ciechanowska, Agata, Pawlik, Katarzyna, Ciapała, Katarzyna, Kocot-Kępska, Magdalena, Makuch, Wioletta, Wordliczek, Jerzy, Mika, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780738/ https://www.ncbi.nlm.nih.gov/pubmed/35056145 http://dx.doi.org/10.3390/ph15010088

Ejemplares similares

Mirogabalin Decreases Pain-like Behaviors by Inhibiting the Microglial/Macrophage Activation, p38MAPK Signaling, and Pronociceptive CCL2 and CCL5 Release in a Mouse Model of Neuropathic Pain
por: Zajączkowska, Renata, et al.
Publicado: (2023)

Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2021)

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain
por: Zajaczkowska, Renata, et al.
Publicado: (2020)

Phenytoin Decreases Pain-like Behaviors and Improves Opioid Analgesia in a Rat Model of Neuropathic Pain
por: Kocot-Kępska, Magdalena, et al.
Publicado: (2023)

Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
por: Piotrowska, Anna, et al.
Publicado: (2018)

Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain
por: Ciapała, Katarzyna, et al.
Publicado: (2023)

Peripheral Mechanisms of Neuropathic Pain—The Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain
por: Kocot-Kępska, Magdalena, et al.
Publicado: (2021)

Mirogabalin—A Novel Selective Ligand for the α2δ Calcium Channel Subunit
por: Zajączkowska, Renata, et al.
Publicado: (2021)

Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury
por: Piotrowska, Anna, et al.
Publicado: (2019)

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
por: Rojewska, Ewelina, et al.
Publicado: (2018)

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies
por: Ciechanowska, Agata, et al.
Publicado: (2022)

Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain—Narrative Review
por: Kocot-Kępska, Magdalena, et al.
Publicado: (2021)

Bone Pain in Cancer Patients: Mechanisms and Current Treatment
por: Zajączkowska, Renata, et al.
Publicado: (2019)

Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence from a Mouse Model
por: Ciechanowska, Agata, et al.
Publicado: (2023)

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain
por: Mika, Joanna, et al.
Publicado: (2014)

Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—In Vivo and In Vitro Study
por: Piotrowska, Anna, et al.
Publicado: (2021)

Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2022)

The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives
por: Ciapała, Katarzyna, et al.
Publicado: (2021)

Perioperative Immunosuppression and Risk of Cancer Progression: The Impact of Opioids on Pain Management
por: Zajączkowska, Renata, et al.
Publicado: (2018)

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2014)

The role of complementary and alternative methods in the treatment of pain in patients with cancer – current evidence and clinical practice: a narrative review
por: Kocot-Kępska, Magdalena, et al.
Publicado: (2021)

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
por: Zajączkowska, Renata, et al.
Publicado: (2019)

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model
por: Jurga, Agnieszka M., et al.
Publicado: (2016)

Bidirectional Action of Cenicriviroc, a CCR2/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy
por: Kwiatkowski, Klaudia, et al.
Publicado: (2020)

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats
por: Kwiatkowski, Klaudia, et al.
Publicado: (2017)

CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
por: Bogacka, Joanna, et al.
Publicado: (2022)

Botulinum Toxin Type A—A Modulator of Spinal Neuron–Glia Interactions under Neuropathic Pain Conditions
por: Rojewska, Ewelina, et al.
Publicado: (2018)

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2015)

Therapeutic Effect of Mirogabalin on Peripheral Neuropathic Pain due to Lumbar Spine Disease
por: Kim, Kyongsong, et al.
Publicado: (2021)

Mirogabalin, a selective gabapentinoid for managing neuropathic pain—A curtain raiser
por: Nair, Abhijit
Publicado: (2022)

The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids
por: Tang, Hui, et al.
Publicado: (2023)

Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics
por: Ciapała, Katarzyna, et al.
Publicado: (2023)

Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study
por: Tetsunaga, Tomoko, et al.
Publicado: (2020)

Long‐term safety and efficacy of mirogabalin in Asian patients with diabetic peripheral neuropathic pain
por: Baba, Masayuki, et al.
Publicado: (2019)

CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain
por: Bogacka, Joanna, et al.
Publicado: (2020)

Transdermal and Topical Drug Administration in the Treatment of Pain
por: Leppert, Wojciech, et al.
Publicado: (2018)

Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2023)

Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain
por: Rojewska, Ewelina, et al.
Publicado: (2014)

Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury—Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model
por: Ciechanowska, Agata, et al.
Publicado: (2020)

Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors
por: Jurga, Agnieszka M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rogedfuko8gjudo19qkqqf7n3p