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Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate...

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Autores principales: Maueia, Cremildo, Murahwa, Alltalents, Manjate, Alice, Andersson, Soren, Sacarlal, Jahit, Kenga, Darlene, Mussá, Tufária, Williamson, Anna-Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780750/
https://www.ncbi.nlm.nih.gov/pubmed/35062228
http://dx.doi.org/10.3390/v14010024
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author Maueia, Cremildo
Murahwa, Alltalents
Manjate, Alice
Andersson, Soren
Sacarlal, Jahit
Kenga, Darlene
Mussá, Tufária
Williamson, Anna-Lise
author_facet Maueia, Cremildo
Murahwa, Alltalents
Manjate, Alice
Andersson, Soren
Sacarlal, Jahit
Kenga, Darlene
Mussá, Tufária
Williamson, Anna-Lise
author_sort Maueia, Cremildo
collection PubMed
description Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.
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spelling pubmed-87807502022-01-22 Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique Maueia, Cremildo Murahwa, Alltalents Manjate, Alice Andersson, Soren Sacarlal, Jahit Kenga, Darlene Mussá, Tufária Williamson, Anna-Lise Viruses Brief Report Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found. MDPI 2021-12-23 /pmc/articles/PMC8780750/ /pubmed/35062228 http://dx.doi.org/10.3390/v14010024 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Maueia, Cremildo
Murahwa, Alltalents
Manjate, Alice
Andersson, Soren
Sacarlal, Jahit
Kenga, Darlene
Mussá, Tufária
Williamson, Anna-Lise
Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title_full Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title_fullStr Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title_full_unstemmed Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title_short Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique
title_sort identification of the human papillomavirus genotypes, according to the human immunodeficiency virus status in a cohort of women from maputo, mozambique
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780750/
https://www.ncbi.nlm.nih.gov/pubmed/35062228
http://dx.doi.org/10.3390/v14010024
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