Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest half-maximal inhibitory concentration (IC(50): 13 nM), SARS-CoV-2 (IC(50): 23 nM), and Middle East respiratory syndrome coronavirus (MERS-CoV;...

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Detalles Bibliográficos
Autores principales: Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M. B., Drelich, Aleksandra, Panda, Siva S., Altieri, Andrea, Kurkin, Alexander V., Tseng, Chien-Te K., Hillyer, Christopher D., Debnath, Asim K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780828/
https://www.ncbi.nlm.nih.gov/pubmed/35062273
http://dx.doi.org/10.3390/v14010069

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