SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the induction of pluripotency, but its molecular mechanisms rema...

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Detalles Bibliográficos
Autores principales: Cha, Young, Kim, Taewoo, Jeon, Jeha, Jang, Yongwoo, Kim, Patrick B., Lopes, Claudia, Leblanc, Pierre, Cohen, Bruce M., Kim, Kwang-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780843/
https://www.ncbi.nlm.nih.gov/pubmed/34965411
http://dx.doi.org/10.1016/j.celrep.2021.110155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780843/
https://www.ncbi.nlm.nih.gov/pubmed/34965411
http://dx.doi.org/10.1016/j.celrep.2021.110155

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