Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation

Peroxisomal fatty acid α-oxidation is an essential pathway for the degradation of β-carbon methylated fatty acids such as phytanic acid. One enzyme in this pathway is 2-hydroxyacyl CoA lyase (HACL1), which is responsible for the cleavage of 2-hydroxyphytanoyl-CoA into pristanal and formyl-CoA. Hacl1...

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Detalles Bibliográficos
Autores principales: Khalil, Youssef, Carrino, Sara, Lin, Fujun, Ferlin, Anna, Lad, Heena V., Mazzacuva, Francesca, Falcone, Sara, Rivers, Natalie, Banks, Gareth, Concas, Danilo, Aguilar, Carlos, Haynes, Andrew R., Blease, Andy, Nicol, Thomas, Al-Shawi, Raya, Heywood, Wendy, Potter, Paul, Mills, Kevin, Gale, Daniel P., Clayton, Peter T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781152/
https://www.ncbi.nlm.nih.gov/pubmed/35055171
http://dx.doi.org/10.3390/ijms23020987

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