Cargando…

A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis

Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neu...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinger, Thiemo Florin, Eerikäinen, Maija Susanna, Michel, Anna, Gembruch, Oliver, Darkwah Oppong, Marvin, Chihi, Mehdi, Blau, Tobias, Uerschels, Anne-Kathrin, Pierscianek, Daniela, Deuschl, Cornelius, Jabbarli, Ramazan, Sure, Ulrich, Wrede, Karsten Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781155/
https://www.ncbi.nlm.nih.gov/pubmed/35054059
http://dx.doi.org/10.3390/jcm11020366
_version_ 1784638021587435520
author Dinger, Thiemo Florin
Eerikäinen, Maija Susanna
Michel, Anna
Gembruch, Oliver
Darkwah Oppong, Marvin
Chihi, Mehdi
Blau, Tobias
Uerschels, Anne-Kathrin
Pierscianek, Daniela
Deuschl, Cornelius
Jabbarli, Ramazan
Sure, Ulrich
Wrede, Karsten Henning
author_facet Dinger, Thiemo Florin
Eerikäinen, Maija Susanna
Michel, Anna
Gembruch, Oliver
Darkwah Oppong, Marvin
Chihi, Mehdi
Blau, Tobias
Uerschels, Anne-Kathrin
Pierscianek, Daniela
Deuschl, Cornelius
Jabbarli, Ramazan
Sure, Ulrich
Wrede, Karsten Henning
author_sort Dinger, Thiemo Florin
collection PubMed
description Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, optimal treatment, and outcome of these patients remain unclear. This study aims to widen current knowledge about this “SEL subform” and to improve its clinical management. A systematic literature review according to the PRISMA guidelines using PubMed, Scopus, Web of Science, and Cochrane Library was used to identify publications before 7 November 2021 reporting on acute/rapidly progressing, severe SEL. The final analysis comprised 12 patients with acute, severe SEL. The majority of the patients were male (9/12) and multimorbid (10/12). SEL mainly affected the thoracic part of the spinal cord (11/12), extending a median number of 7 spinal levels (range: 4–19). Surgery was the only chosen therapy (11/12), except for one critically ill patient. Regarding the outcome, half of the patients regained independence (6/11; = modified McCormick Scale ≤ II). Acute, severe SEL is a rare condition, mainly affecting multimorbid patients. The prognosis is poor in nearly 50% of the patients, even with maximum therapy. Further research is needed to stratify patients for conservative or surgical treatment.
format Online
Article
Text
id pubmed-8781155
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87811552022-01-22 A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis Dinger, Thiemo Florin Eerikäinen, Maija Susanna Michel, Anna Gembruch, Oliver Darkwah Oppong, Marvin Chihi, Mehdi Blau, Tobias Uerschels, Anne-Kathrin Pierscianek, Daniela Deuschl, Cornelius Jabbarli, Ramazan Sure, Ulrich Wrede, Karsten Henning J Clin Med Article Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, optimal treatment, and outcome of these patients remain unclear. This study aims to widen current knowledge about this “SEL subform” and to improve its clinical management. A systematic literature review according to the PRISMA guidelines using PubMed, Scopus, Web of Science, and Cochrane Library was used to identify publications before 7 November 2021 reporting on acute/rapidly progressing, severe SEL. The final analysis comprised 12 patients with acute, severe SEL. The majority of the patients were male (9/12) and multimorbid (10/12). SEL mainly affected the thoracic part of the spinal cord (11/12), extending a median number of 7 spinal levels (range: 4–19). Surgery was the only chosen therapy (11/12), except for one critically ill patient. Regarding the outcome, half of the patients regained independence (6/11; = modified McCormick Scale ≤ II). Acute, severe SEL is a rare condition, mainly affecting multimorbid patients. The prognosis is poor in nearly 50% of the patients, even with maximum therapy. Further research is needed to stratify patients for conservative or surgical treatment. MDPI 2022-01-12 /pmc/articles/PMC8781155/ /pubmed/35054059 http://dx.doi.org/10.3390/jcm11020366 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dinger, Thiemo Florin
Eerikäinen, Maija Susanna
Michel, Anna
Gembruch, Oliver
Darkwah Oppong, Marvin
Chihi, Mehdi
Blau, Tobias
Uerschels, Anne-Kathrin
Pierscianek, Daniela
Deuschl, Cornelius
Jabbarli, Ramazan
Sure, Ulrich
Wrede, Karsten Henning
A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title_full A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title_fullStr A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title_full_unstemmed A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title_short A New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis
title_sort new subform? fast-progressing, severe neurological deterioration caused by spinal epidural lipomatosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781155/
https://www.ncbi.nlm.nih.gov/pubmed/35054059
http://dx.doi.org/10.3390/jcm11020366
work_keys_str_mv AT dingerthiemoflorin anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT eerikainenmaijasusanna anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT michelanna anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT gembrucholiver anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT darkwahoppongmarvin anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT chihimehdi anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT blautobias anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT uerschelsannekathrin anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT pierscianekdaniela anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT deuschlcornelius anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT jabbarliramazan anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT sureulrich anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT wredekarstenhenning anewsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT dingerthiemoflorin newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT eerikainenmaijasusanna newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT michelanna newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT gembrucholiver newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT darkwahoppongmarvin newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT chihimehdi newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT blautobias newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT uerschelsannekathrin newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT pierscianekdaniela newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT deuschlcornelius newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT jabbarliramazan newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT sureulrich newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis
AT wredekarstenhenning newsubformfastprogressingsevereneurologicaldeteriorationcausedbyspinalepidurallipomatosis