Chevalones H–M: Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001

Six new α-pyrone meroterpenoid chevalones H–M (1–6), together with six known compounds (7–12), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures, including absolute configurations, were eluc...

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Detalles Bibliográficos
Autores principales: Chen, Xia-Yu, Zeng, Qi, Chen, Yu-Chan, Zhong, Wei-Mao, Xiang, Yao, Wang, Jun-Feng, Shi, Xue-Feng, Zhang, Wei-Min, Zhang, Si, Wang, Fa-Zuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781156/
https://www.ncbi.nlm.nih.gov/pubmed/35049926
http://dx.doi.org/10.3390/md20010071
Descripción
Sumario:Six new α-pyrone meroterpenoid chevalones H–M (1–6), together with six known compounds (7–12), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures, including absolute configurations, were elucidated on the basis of spectroscopic analysis and X-ray diffraction data. Compounds 1–5 and 7 showed different degrees of antibacterial activity with MIC values of 6.25–100 μg/mL. Compound 8 exhibited potent cytotoxicity against SF-268, MCF-7, and A549 cell lines with IC(50) values of 12.75, 9.29, and 20.11 μM, respectively.

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