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Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications

This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successf...

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Autores principales: David, Madalina Elena, Ion, Rodica Mariana, Grigorescu, Ramona Marina, Iancu, Lorena, Holban, Alina Maria, Iordache, Florin, Nicoara, Adrian Ionut, Alexandrescu, Elvira, Somoghi, Raluca, Teodorescu, Sofia, Gheboianu, Anca Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781191/
https://www.ncbi.nlm.nih.gov/pubmed/35055256
http://dx.doi.org/10.3390/nano12020239
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author David, Madalina Elena
Ion, Rodica Mariana
Grigorescu, Ramona Marina
Iancu, Lorena
Holban, Alina Maria
Iordache, Florin
Nicoara, Adrian Ionut
Alexandrescu, Elvira
Somoghi, Raluca
Teodorescu, Sofia
Gheboianu, Anca Irina
author_facet David, Madalina Elena
Ion, Rodica Mariana
Grigorescu, Ramona Marina
Iancu, Lorena
Holban, Alina Maria
Iordache, Florin
Nicoara, Adrian Ionut
Alexandrescu, Elvira
Somoghi, Raluca
Teodorescu, Sofia
Gheboianu, Anca Irina
author_sort David, Madalina Elena
collection PubMed
description This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO(2) NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial.
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spelling pubmed-87811912022-01-22 Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications David, Madalina Elena Ion, Rodica Mariana Grigorescu, Ramona Marina Iancu, Lorena Holban, Alina Maria Iordache, Florin Nicoara, Adrian Ionut Alexandrescu, Elvira Somoghi, Raluca Teodorescu, Sofia Gheboianu, Anca Irina Nanomaterials (Basel) Article This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO(2) NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial. MDPI 2022-01-12 /pmc/articles/PMC8781191/ /pubmed/35055256 http://dx.doi.org/10.3390/nano12020239 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
David, Madalina Elena
Ion, Rodica Mariana
Grigorescu, Ramona Marina
Iancu, Lorena
Holban, Alina Maria
Iordache, Florin
Nicoara, Adrian Ionut
Alexandrescu, Elvira
Somoghi, Raluca
Teodorescu, Sofia
Gheboianu, Anca Irina
Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title_full Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title_fullStr Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title_full_unstemmed Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title_short Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
title_sort biocompatible and antimicrobial cellulose acetate-collagen films containing mwcnts decorated with tio(2) nanoparticles for potential biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781191/
https://www.ncbi.nlm.nih.gov/pubmed/35055256
http://dx.doi.org/10.3390/nano12020239
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