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Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications
This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successf...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781191/ https://www.ncbi.nlm.nih.gov/pubmed/35055256 http://dx.doi.org/10.3390/nano12020239 |
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author | David, Madalina Elena Ion, Rodica Mariana Grigorescu, Ramona Marina Iancu, Lorena Holban, Alina Maria Iordache, Florin Nicoara, Adrian Ionut Alexandrescu, Elvira Somoghi, Raluca Teodorescu, Sofia Gheboianu, Anca Irina |
author_facet | David, Madalina Elena Ion, Rodica Mariana Grigorescu, Ramona Marina Iancu, Lorena Holban, Alina Maria Iordache, Florin Nicoara, Adrian Ionut Alexandrescu, Elvira Somoghi, Raluca Teodorescu, Sofia Gheboianu, Anca Irina |
author_sort | David, Madalina Elena |
collection | PubMed |
description | This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO(2) NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial. |
format | Online Article Text |
id | pubmed-8781191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87811912022-01-22 Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications David, Madalina Elena Ion, Rodica Mariana Grigorescu, Ramona Marina Iancu, Lorena Holban, Alina Maria Iordache, Florin Nicoara, Adrian Ionut Alexandrescu, Elvira Somoghi, Raluca Teodorescu, Sofia Gheboianu, Anca Irina Nanomaterials (Basel) Article This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO(2) nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO(2) NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial. MDPI 2022-01-12 /pmc/articles/PMC8781191/ /pubmed/35055256 http://dx.doi.org/10.3390/nano12020239 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article David, Madalina Elena Ion, Rodica Mariana Grigorescu, Ramona Marina Iancu, Lorena Holban, Alina Maria Iordache, Florin Nicoara, Adrian Ionut Alexandrescu, Elvira Somoghi, Raluca Teodorescu, Sofia Gheboianu, Anca Irina Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title | Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title_full | Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title_fullStr | Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title_full_unstemmed | Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title_short | Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO(2) Nanoparticles for Potential Biomedical Applications |
title_sort | biocompatible and antimicrobial cellulose acetate-collagen films containing mwcnts decorated with tio(2) nanoparticles for potential biomedical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781191/ https://www.ncbi.nlm.nih.gov/pubmed/35055256 http://dx.doi.org/10.3390/nano12020239 |
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