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Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS

Patients with bronchiectasis feature considerable symptom burden and reduced health-related quality of life (QOL). We provide the psychometric validation of the German translation of the disease-specific Quality of Life Questionnaire-Bronchiectasis (QOL-B), version 3.1, using baseline data of adults...

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Autores principales: Quellhorst, Laura, Barten-Neiner, Grit, de Roux, Andrés, Diel, Roland, Mertsch, Pontus, Pink, Isabell, Rademacher, Jessica, Sutharsan, Sivagurunathan, Welte, Tobias, Zurawski, Annegret, Ringshausen, Felix C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781204/
https://www.ncbi.nlm.nih.gov/pubmed/35054135
http://dx.doi.org/10.3390/jcm11020441
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author Quellhorst, Laura
Barten-Neiner, Grit
de Roux, Andrés
Diel, Roland
Mertsch, Pontus
Pink, Isabell
Rademacher, Jessica
Sutharsan, Sivagurunathan
Welte, Tobias
Zurawski, Annegret
Ringshausen, Felix C.
author_facet Quellhorst, Laura
Barten-Neiner, Grit
de Roux, Andrés
Diel, Roland
Mertsch, Pontus
Pink, Isabell
Rademacher, Jessica
Sutharsan, Sivagurunathan
Welte, Tobias
Zurawski, Annegret
Ringshausen, Felix C.
author_sort Quellhorst, Laura
collection PubMed
description Patients with bronchiectasis feature considerable symptom burden and reduced health-related quality of life (QOL). We provide the psychometric validation of the German translation of the disease-specific Quality of Life Questionnaire-Bronchiectasis (QOL-B), version 3.1, using baseline data of adults consecutively enrolled into the prospective German bronchiectasis registry PROGNOSIS. Overall, 904 patients with evaluable QOL-B scores were included. We observed no relevant floor or ceiling effects. Internal consistency was good to excellent (Cronbach’s α ≥0.73 for each scale). QOL-B scales discriminated between patients based on prior pulmonary exacerbations and hospitalizations, breathlessness, bronchiectasis severity index, lung function, sputum volume, Pseudomonas aeruginosa status and the need for regular pharmacotherapy, except for Social Functioning, Vitality and Emotional Functioning scales. We observed moderate to strong convergence between several measures of disease severity and QOL-B scales, except for Social and Emotional Functioning. Two-week test-retest reliability was good, with intraclass correlation coefficients ≥0.84 for each scale. Minimal clinical important difference ranged between 8.5 for the Respiratory Symptoms and 14.1 points for the Social Functioning scale. Overall, the German translation of the QOL-B, version 3.1, has good validity and test-retest reliability among a nationally representative adult bronchiectasis cohort. However, responsiveness of QOL-B scales require further investigation during registry follow-up.
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spelling pubmed-87812042022-01-22 Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS Quellhorst, Laura Barten-Neiner, Grit de Roux, Andrés Diel, Roland Mertsch, Pontus Pink, Isabell Rademacher, Jessica Sutharsan, Sivagurunathan Welte, Tobias Zurawski, Annegret Ringshausen, Felix C. J Clin Med Article Patients with bronchiectasis feature considerable symptom burden and reduced health-related quality of life (QOL). We provide the psychometric validation of the German translation of the disease-specific Quality of Life Questionnaire-Bronchiectasis (QOL-B), version 3.1, using baseline data of adults consecutively enrolled into the prospective German bronchiectasis registry PROGNOSIS. Overall, 904 patients with evaluable QOL-B scores were included. We observed no relevant floor or ceiling effects. Internal consistency was good to excellent (Cronbach’s α ≥0.73 for each scale). QOL-B scales discriminated between patients based on prior pulmonary exacerbations and hospitalizations, breathlessness, bronchiectasis severity index, lung function, sputum volume, Pseudomonas aeruginosa status and the need for regular pharmacotherapy, except for Social Functioning, Vitality and Emotional Functioning scales. We observed moderate to strong convergence between several measures of disease severity and QOL-B scales, except for Social and Emotional Functioning. Two-week test-retest reliability was good, with intraclass correlation coefficients ≥0.84 for each scale. Minimal clinical important difference ranged between 8.5 for the Respiratory Symptoms and 14.1 points for the Social Functioning scale. Overall, the German translation of the QOL-B, version 3.1, has good validity and test-retest reliability among a nationally representative adult bronchiectasis cohort. However, responsiveness of QOL-B scales require further investigation during registry follow-up. MDPI 2022-01-15 /pmc/articles/PMC8781204/ /pubmed/35054135 http://dx.doi.org/10.3390/jcm11020441 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quellhorst, Laura
Barten-Neiner, Grit
de Roux, Andrés
Diel, Roland
Mertsch, Pontus
Pink, Isabell
Rademacher, Jessica
Sutharsan, Sivagurunathan
Welte, Tobias
Zurawski, Annegret
Ringshausen, Felix C.
Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title_full Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title_fullStr Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title_full_unstemmed Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title_short Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
title_sort psychometric validation of the german translation of the quality of life questionnaire-bronchiectasis (qol-b)—data from the german bronchiectasis registry prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781204/
https://www.ncbi.nlm.nih.gov/pubmed/35054135
http://dx.doi.org/10.3390/jcm11020441
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