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Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome

Purpose: To evaluate the effectiveness of different treatment modalities for dry eye in primary Sjögren’s syndrome with their potential overlapping influences. Methods: This study included 199 patients with newly diagnosed primary Sjögren’s syndrome from 2005 to 2020. Various treatment modalities fo...

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Autores principales: Ahn, Hyunmin, Ji, Yong Woo, Jun, Ikhyun, Kim, Tae-im, Lee, Hyung Keun, Seo, Kyoung Yul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781254/
https://www.ncbi.nlm.nih.gov/pubmed/35054155
http://dx.doi.org/10.3390/jcm11020463
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author Ahn, Hyunmin
Ji, Yong Woo
Jun, Ikhyun
Kim, Tae-im
Lee, Hyung Keun
Seo, Kyoung Yul
author_facet Ahn, Hyunmin
Ji, Yong Woo
Jun, Ikhyun
Kim, Tae-im
Lee, Hyung Keun
Seo, Kyoung Yul
author_sort Ahn, Hyunmin
collection PubMed
description Purpose: To evaluate the effectiveness of different treatment modalities for dry eye in primary Sjögren’s syndrome with their potential overlapping influences. Methods: This study included 199 patients with newly diagnosed primary Sjögren’s syndrome from 2005 to 2020. Various treatment modalities for primary Sjögren’s syndrome were compared. Improvement of corneal staining based on Sjögren’s International Collaborative Clinical Alliance (SICCA) scores was the primary outcome. Results: The average follow-up period was 5.4 ± 3.1 (range, 2.0–14.1) years. Analysis of the individual treatments showed that punctal plug insertions in the lower and upper eyelids were strongly associated with improvement of SICCA scores (β = 2.70 and 1.80, p < 0.001 and <0.001, respectively). With ocular surface inflammation, corneal staining scores improved significantly with steroid eye drops. Prednisolone (1%) had the strongest association with improvement of corneal staining scores (β = 1.48, p < 0.001); this was based on the frequency of administration. Without ocular surface inflammation, diquafosol (3%), carbomer gel, and lanolin ointment were effective (β = 1.37, 1.06, and 1.17; p = 0.003, 0.003, and <0.001, respectively). Conclusions: Punctal plug insertion, primarily targeting aqueous deficiency, is the mainstay of the treatment for dry eye in primary Sjögren’s syndrome even in the presence of ocular surface inflammation. Furthermore, the effectiveness of treatment modalities for dry eye in primary Sjögren’s syndrome was dependent on the presence of ocular surface inflammation.
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spelling pubmed-87812542022-01-22 Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome Ahn, Hyunmin Ji, Yong Woo Jun, Ikhyun Kim, Tae-im Lee, Hyung Keun Seo, Kyoung Yul J Clin Med Article Purpose: To evaluate the effectiveness of different treatment modalities for dry eye in primary Sjögren’s syndrome with their potential overlapping influences. Methods: This study included 199 patients with newly diagnosed primary Sjögren’s syndrome from 2005 to 2020. Various treatment modalities for primary Sjögren’s syndrome were compared. Improvement of corneal staining based on Sjögren’s International Collaborative Clinical Alliance (SICCA) scores was the primary outcome. Results: The average follow-up period was 5.4 ± 3.1 (range, 2.0–14.1) years. Analysis of the individual treatments showed that punctal plug insertions in the lower and upper eyelids were strongly associated with improvement of SICCA scores (β = 2.70 and 1.80, p < 0.001 and <0.001, respectively). With ocular surface inflammation, corneal staining scores improved significantly with steroid eye drops. Prednisolone (1%) had the strongest association with improvement of corneal staining scores (β = 1.48, p < 0.001); this was based on the frequency of administration. Without ocular surface inflammation, diquafosol (3%), carbomer gel, and lanolin ointment were effective (β = 1.37, 1.06, and 1.17; p = 0.003, 0.003, and <0.001, respectively). Conclusions: Punctal plug insertion, primarily targeting aqueous deficiency, is the mainstay of the treatment for dry eye in primary Sjögren’s syndrome even in the presence of ocular surface inflammation. Furthermore, the effectiveness of treatment modalities for dry eye in primary Sjögren’s syndrome was dependent on the presence of ocular surface inflammation. MDPI 2022-01-17 /pmc/articles/PMC8781254/ /pubmed/35054155 http://dx.doi.org/10.3390/jcm11020463 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahn, Hyunmin
Ji, Yong Woo
Jun, Ikhyun
Kim, Tae-im
Lee, Hyung Keun
Seo, Kyoung Yul
Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title_full Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title_fullStr Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title_full_unstemmed Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title_short Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome
title_sort comparison of treatment modalities for dry eye in primary sjögren’s syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781254/
https://www.ncbi.nlm.nih.gov/pubmed/35054155
http://dx.doi.org/10.3390/jcm11020463
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