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Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood

Light exerts powerful biological effects on mood regulation. Whereas the source of photic information affecting mood is well established at least via intrinsically photosensitive retinal ganglion cells (ipRGCs) secreting the melanopsin photopigment, the precise circuits that mediate the impact of li...

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Autores principales: Maruani, Julia, Geoffroy, Pierre A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781294/
https://www.ncbi.nlm.nih.gov/pubmed/35054142
http://dx.doi.org/10.3390/jcm11020448
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author Maruani, Julia
Geoffroy, Pierre A.
author_facet Maruani, Julia
Geoffroy, Pierre A.
author_sort Maruani, Julia
collection PubMed
description Light exerts powerful biological effects on mood regulation. Whereas the source of photic information affecting mood is well established at least via intrinsically photosensitive retinal ganglion cells (ipRGCs) secreting the melanopsin photopigment, the precise circuits that mediate the impact of light on depressive behaviors are not well understood. This review proposes two distinct retina–brain pathways of light effects on mood: (i) a suprachiasmatic nucleus (SCN)-dependent pathway with light effect on mood via the synchronization of biological rhythms, and (ii) a SCN-independent pathway with light effects on mood through modulation of the homeostatic process of sleep, alertness and emotion regulation: (1) light directly inhibits brain areas promoting sleep such as the ventrolateral preoptic nucleus (VLPO), and activates numerous brain areas involved in alertness such as, monoaminergic areas, thalamic regions and hypothalamic regions including orexin areas; (2) moreover, light seems to modulate mood through orexin-, serotonin- and dopamine-dependent pathways; (3) in addition, light activates brain emotional processing areas including the amygdala, the nucleus accumbens, the perihabenular nucleus, the left hippocampus and pathways such as the retina–ventral lateral geniculate nucleus and intergeniculate leaflet–lateral habenula pathway. This work synthetizes new insights into the neural basis required for light influence mood
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spelling pubmed-87812942022-01-22 Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood Maruani, Julia Geoffroy, Pierre A. J Clin Med Review Light exerts powerful biological effects on mood regulation. Whereas the source of photic information affecting mood is well established at least via intrinsically photosensitive retinal ganglion cells (ipRGCs) secreting the melanopsin photopigment, the precise circuits that mediate the impact of light on depressive behaviors are not well understood. This review proposes two distinct retina–brain pathways of light effects on mood: (i) a suprachiasmatic nucleus (SCN)-dependent pathway with light effect on mood via the synchronization of biological rhythms, and (ii) a SCN-independent pathway with light effects on mood through modulation of the homeostatic process of sleep, alertness and emotion regulation: (1) light directly inhibits brain areas promoting sleep such as the ventrolateral preoptic nucleus (VLPO), and activates numerous brain areas involved in alertness such as, monoaminergic areas, thalamic regions and hypothalamic regions including orexin areas; (2) moreover, light seems to modulate mood through orexin-, serotonin- and dopamine-dependent pathways; (3) in addition, light activates brain emotional processing areas including the amygdala, the nucleus accumbens, the perihabenular nucleus, the left hippocampus and pathways such as the retina–ventral lateral geniculate nucleus and intergeniculate leaflet–lateral habenula pathway. This work synthetizes new insights into the neural basis required for light influence mood MDPI 2022-01-16 /pmc/articles/PMC8781294/ /pubmed/35054142 http://dx.doi.org/10.3390/jcm11020448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maruani, Julia
Geoffroy, Pierre A.
Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title_full Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title_fullStr Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title_full_unstemmed Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title_short Multi-Level Processes and Retina–Brain Pathways of Photic Regulation of Mood
title_sort multi-level processes and retina–brain pathways of photic regulation of mood
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781294/
https://www.ncbi.nlm.nih.gov/pubmed/35054142
http://dx.doi.org/10.3390/jcm11020448
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