Tandem Substitutions in Somatic Hypermutation

Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but tandem substitutions may also occur. We investigated...

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Detalles Bibliográficos
Autores principales: Sepúlveda-Yáñez, Julieta H., Alvarez Saravia, Diego, Pilzecker, Bas, van Schouwenburg, Pauline A., van den Burg, Mirjam, Veelken, Hendrik, Navarrete, Marcelo A., Jacobs, Heinz, Koning, Marvyn T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781386/
https://www.ncbi.nlm.nih.gov/pubmed/35069591
http://dx.doi.org/10.3389/fimmu.2021.807015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781386/
https://www.ncbi.nlm.nih.gov/pubmed/35069591
http://dx.doi.org/10.3389/fimmu.2021.807015

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