The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions...

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Autores principales: Dabravolski, Siarhei A., Khotina, Victoria A., Omelchenko, Andrey V., Kalmykov, Vladislav A., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781560/
https://www.ncbi.nlm.nih.gov/pubmed/35055117
http://dx.doi.org/10.3390/ijms23020931
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author Dabravolski, Siarhei A.
Khotina, Victoria A.
Omelchenko, Andrey V.
Kalmykov, Vladislav A.
Orekhov, Alexander N.
author_facet Dabravolski, Siarhei A.
Khotina, Victoria A.
Omelchenko, Andrey V.
Kalmykov, Vladislav A.
Orekhov, Alexander N.
author_sort Dabravolski, Siarhei A.
collection PubMed
description The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs’ treatment.
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spelling pubmed-87815602022-01-22 The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets Dabravolski, Siarhei A. Khotina, Victoria A. Omelchenko, Andrey V. Kalmykov, Vladislav A. Orekhov, Alexander N. Int J Mol Sci Review The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs’ treatment. MDPI 2022-01-15 /pmc/articles/PMC8781560/ /pubmed/35055117 http://dx.doi.org/10.3390/ijms23020931 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dabravolski, Siarhei A.
Khotina, Victoria A.
Omelchenko, Andrey V.
Kalmykov, Vladislav A.
Orekhov, Alexander N.
The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title_full The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title_fullStr The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title_full_unstemmed The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title_short The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
title_sort role of the vegf family in atherosclerosis development and its potential as treatment targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781560/
https://www.ncbi.nlm.nih.gov/pubmed/35055117
http://dx.doi.org/10.3390/ijms23020931
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