Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice

Legionnaires’ disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulen...

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Autores principales: Trousil, Jiří, Frgelecová, Lucia, Kubíčková, Pavla, Řeháková, Kristína, Drašar, Vladimír, Matějková, Jana, Štěpánek, Petr, Pavliš, Oto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781576/
https://www.ncbi.nlm.nih.gov/pubmed/35056629
http://dx.doi.org/10.3390/microorganisms10010179
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author Trousil, Jiří
Frgelecová, Lucia
Kubíčková, Pavla
Řeháková, Kristína
Drašar, Vladimír
Matějková, Jana
Štěpánek, Petr
Pavliš, Oto
author_facet Trousil, Jiří
Frgelecová, Lucia
Kubíčková, Pavla
Řeháková, Kristína
Drašar, Vladimír
Matějková, Jana
Štěpánek, Petr
Pavliš, Oto
author_sort Trousil, Jiří
collection PubMed
description Legionnaires’ disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of L. pneumophila serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 10(4) and 10(6) CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires’ disease has been described in detail.
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spelling pubmed-87815762022-01-22 Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice Trousil, Jiří Frgelecová, Lucia Kubíčková, Pavla Řeháková, Kristína Drašar, Vladimír Matějková, Jana Štěpánek, Petr Pavliš, Oto Microorganisms Article Legionnaires’ disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of L. pneumophila serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 10(4) and 10(6) CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires’ disease has been described in detail. MDPI 2022-01-14 /pmc/articles/PMC8781576/ /pubmed/35056629 http://dx.doi.org/10.3390/microorganisms10010179 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trousil, Jiří
Frgelecová, Lucia
Kubíčková, Pavla
Řeháková, Kristína
Drašar, Vladimír
Matějková, Jana
Štěpánek, Petr
Pavliš, Oto
Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title_full Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title_fullStr Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title_full_unstemmed Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title_short Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice
title_sort acute pneumonia caused by clinically isolated legionella pneumophila sg 1, st 62: host responses and pathologies in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781576/
https://www.ncbi.nlm.nih.gov/pubmed/35056629
http://dx.doi.org/10.3390/microorganisms10010179
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