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Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction

C-reactive protein velocity (CRPv), defined as the change in wide-range CRP concentration divided by time, is an inflammatory biomarker associated with increased morbidity and mortality in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (PCI)....

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Autores principales: Banai, Ariel, Levit, Dana, Morgan, Samuel, Loewenstein, Itamar, Merdler, Ilan, Hochstadt, Aviram, Szekely, Yishay, Topilsky, Yan, Banai, Shmuel, Shacham, Yacov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781585/
https://www.ncbi.nlm.nih.gov/pubmed/35054095
http://dx.doi.org/10.3390/jcm11020401
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author Banai, Ariel
Levit, Dana
Morgan, Samuel
Loewenstein, Itamar
Merdler, Ilan
Hochstadt, Aviram
Szekely, Yishay
Topilsky, Yan
Banai, Shmuel
Shacham, Yacov
author_facet Banai, Ariel
Levit, Dana
Morgan, Samuel
Loewenstein, Itamar
Merdler, Ilan
Hochstadt, Aviram
Szekely, Yishay
Topilsky, Yan
Banai, Shmuel
Shacham, Yacov
author_sort Banai, Ariel
collection PubMed
description C-reactive protein velocity (CRPv), defined as the change in wide-range CRP concentration divided by time, is an inflammatory biomarker associated with increased morbidity and mortality in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (PCI). However, data regarding CRPv association with echocardiographic parameters assessing left ventricular systolic and diastolic function is lacking. Echocardiographic parameters and CRPv values were analyzed using a cohort of 1059 patients admitted with STEMI and treated with primary PCI. Patients were stratified into tertiles according to their CRPv. A receiver operating characteristic (ROC) curve was used to evaluate CRPv optimal cut-off values for the prediction of severe systolic and diastolic dysfunction. Patients with high CRPv tertiles had lower left ventricular ejection fraction (LVEF) (49% vs. 46% vs. 41%, respectively; p < 0.001). CRPv was found to independently predict LVEF ≤ 35% (HR 1.3 CI 95% 1.21–1.4; p < 0.001) and grade III diastolic dysfunction (HR 1.16 CI 95% 11.02–1.31; p = 0.02). CRPv exhibited a better diagnostic profile for severe systolic dysfunction as compared to CRP (area under the curve 0.734 ± 0.02 vs. 0.608 ± 0.02). In conclusion, For STEMI patients treated with primary PCI, CRPv is a marker of both systolic and diastolic dysfunction. Further larger studies are needed to support this finding.
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spelling pubmed-87815852022-01-22 Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction Banai, Ariel Levit, Dana Morgan, Samuel Loewenstein, Itamar Merdler, Ilan Hochstadt, Aviram Szekely, Yishay Topilsky, Yan Banai, Shmuel Shacham, Yacov J Clin Med Article C-reactive protein velocity (CRPv), defined as the change in wide-range CRP concentration divided by time, is an inflammatory biomarker associated with increased morbidity and mortality in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (PCI). However, data regarding CRPv association with echocardiographic parameters assessing left ventricular systolic and diastolic function is lacking. Echocardiographic parameters and CRPv values were analyzed using a cohort of 1059 patients admitted with STEMI and treated with primary PCI. Patients were stratified into tertiles according to their CRPv. A receiver operating characteristic (ROC) curve was used to evaluate CRPv optimal cut-off values for the prediction of severe systolic and diastolic dysfunction. Patients with high CRPv tertiles had lower left ventricular ejection fraction (LVEF) (49% vs. 46% vs. 41%, respectively; p < 0.001). CRPv was found to independently predict LVEF ≤ 35% (HR 1.3 CI 95% 1.21–1.4; p < 0.001) and grade III diastolic dysfunction (HR 1.16 CI 95% 11.02–1.31; p = 0.02). CRPv exhibited a better diagnostic profile for severe systolic dysfunction as compared to CRP (area under the curve 0.734 ± 0.02 vs. 0.608 ± 0.02). In conclusion, For STEMI patients treated with primary PCI, CRPv is a marker of both systolic and diastolic dysfunction. Further larger studies are needed to support this finding. MDPI 2022-01-13 /pmc/articles/PMC8781585/ /pubmed/35054095 http://dx.doi.org/10.3390/jcm11020401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banai, Ariel
Levit, Dana
Morgan, Samuel
Loewenstein, Itamar
Merdler, Ilan
Hochstadt, Aviram
Szekely, Yishay
Topilsky, Yan
Banai, Shmuel
Shacham, Yacov
Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title_full Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title_fullStr Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title_full_unstemmed Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title_short Association between C-Reactive Protein Velocity and Left Ventricular Function in Patients with ST-Elevated Myocardial Infarction
title_sort association between c-reactive protein velocity and left ventricular function in patients with st-elevated myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781585/
https://www.ncbi.nlm.nih.gov/pubmed/35054095
http://dx.doi.org/10.3390/jcm11020401
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