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Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults

Mumps outbreaks and breakthrough infections of measles and rubella have raised concerns about waning of vaccine-induced immunity after two doses of measles-mumps-rubella (MMR) vaccination. In the present follow-up study, serum IgG antibodies against mumps, measles and rubella, as well as the functio...

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Autores principales: Kaaijk, Patricia, Wijmenga-Monsuur, Alienke J., Hulscher, Hinke I. ten, Kerkhof, Jeroen, Smits, Gaby, Nicolaie, Mioara Alina, van Houten, Marianne A., van Binnendijk, Rob S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781586/
https://www.ncbi.nlm.nih.gov/pubmed/35062794
http://dx.doi.org/10.3390/vaccines10010132
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author Kaaijk, Patricia
Wijmenga-Monsuur, Alienke J.
Hulscher, Hinke I. ten
Kerkhof, Jeroen
Smits, Gaby
Nicolaie, Mioara Alina
van Houten, Marianne A.
van Binnendijk, Rob S.
author_facet Kaaijk, Patricia
Wijmenga-Monsuur, Alienke J.
Hulscher, Hinke I. ten
Kerkhof, Jeroen
Smits, Gaby
Nicolaie, Mioara Alina
van Houten, Marianne A.
van Binnendijk, Rob S.
author_sort Kaaijk, Patricia
collection PubMed
description Mumps outbreaks and breakthrough infections of measles and rubella have raised concerns about waning of vaccine-induced immunity after two doses of measles-mumps-rubella (MMR) vaccination. In the present follow-up study, serum IgG antibodies against mumps, measles and rubella, as well as the functional neutralizing antibodies against both the mumps vaccine strain and mumps outbreak strains were measured longitudinally in young adults that received a third MMR (MMR3) dose. The mumps-specific IgG and virus neutralizing antibody levels at 3 years after vaccination were still elevated compared to pre-vaccination antibody levels, although the differences were smaller than at earlier timepoints. Interestingly, subjects with low antibody levels to mumps before vaccination benefited the most as they showed the strongest antibody increase after an MMR3 dose. Three years after an MMR3 dose, all subjects had antibody levels to measles and rubella above the internationally agreed antibody cutoff levels for clinical protection. Our data support the recommendation that an MMR3 dose may provide additional protection for those that have become susceptible to mumps virus infection during outbreaks. MMR3 also resulted in an increase in anti-measles and rubella antibody levels that lasted longer than might have been expected.
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spelling pubmed-87815862022-01-22 Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults Kaaijk, Patricia Wijmenga-Monsuur, Alienke J. Hulscher, Hinke I. ten Kerkhof, Jeroen Smits, Gaby Nicolaie, Mioara Alina van Houten, Marianne A. van Binnendijk, Rob S. Vaccines (Basel) Article Mumps outbreaks and breakthrough infections of measles and rubella have raised concerns about waning of vaccine-induced immunity after two doses of measles-mumps-rubella (MMR) vaccination. In the present follow-up study, serum IgG antibodies against mumps, measles and rubella, as well as the functional neutralizing antibodies against both the mumps vaccine strain and mumps outbreak strains were measured longitudinally in young adults that received a third MMR (MMR3) dose. The mumps-specific IgG and virus neutralizing antibody levels at 3 years after vaccination were still elevated compared to pre-vaccination antibody levels, although the differences were smaller than at earlier timepoints. Interestingly, subjects with low antibody levels to mumps before vaccination benefited the most as they showed the strongest antibody increase after an MMR3 dose. Three years after an MMR3 dose, all subjects had antibody levels to measles and rubella above the internationally agreed antibody cutoff levels for clinical protection. Our data support the recommendation that an MMR3 dose may provide additional protection for those that have become susceptible to mumps virus infection during outbreaks. MMR3 also resulted in an increase in anti-measles and rubella antibody levels that lasted longer than might have been expected. MDPI 2022-01-17 /pmc/articles/PMC8781586/ /pubmed/35062794 http://dx.doi.org/10.3390/vaccines10010132 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaaijk, Patricia
Wijmenga-Monsuur, Alienke J.
Hulscher, Hinke I. ten
Kerkhof, Jeroen
Smits, Gaby
Nicolaie, Mioara Alina
van Houten, Marianne A.
van Binnendijk, Rob S.
Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title_full Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title_fullStr Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title_full_unstemmed Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title_short Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults
title_sort antibody levels at 3-years follow-up of a third dose of measles-mumps-rubella vaccine in young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781586/
https://www.ncbi.nlm.nih.gov/pubmed/35062794
http://dx.doi.org/10.3390/vaccines10010132
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