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Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort

Acute respiratory infections (ARIs) are the most common childhood illnesses worldwide whereby the reported frequency varies widely, often depending on type of assessment. Symptom diaries are a powerful tool to counteract possible under-reporting, particularly of milder infections, and thus offer the...

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Autores principales: Langer, Susan, Horn, Johannes, Gottschick, Cornelia, Klee, Bianca, Purschke, Oliver, Caputo, Mahrrouz, Dorendorf, Evelyn, Meyer-Schlinkmann, Kristin Maria, Raupach-Rosin, Heike, Karch, André, Rübsamen, Nicole, Aydogdu, Mustafa, Buhles, Matthias, Dressler, Frank, Eberl, Wolfgang, von Koch, Franz Edler, Frambach, Torsten, Franz, Heiko, Guthmann, Florian, Guzman, Carlos A., Haase, Roland, Hansen, Gesine, Heselich, Valerie, Hübner, Johannes, Koch, Hans Georg, Oberhoff, Carsten, Riese, Peggy, Schild, Ralf, Seeger, Sven, Tchirikov, Michael, Trittel, Stephanie, von Kaisenberg, Constantin, Mikolajczyk, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781593/
https://www.ncbi.nlm.nih.gov/pubmed/35056559
http://dx.doi.org/10.3390/microorganisms10010111
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author Langer, Susan
Horn, Johannes
Gottschick, Cornelia
Klee, Bianca
Purschke, Oliver
Caputo, Mahrrouz
Dorendorf, Evelyn
Meyer-Schlinkmann, Kristin Maria
Raupach-Rosin, Heike
Karch, André
Rübsamen, Nicole
Aydogdu, Mustafa
Buhles, Matthias
Dressler, Frank
Eberl, Wolfgang
von Koch, Franz Edler
Frambach, Torsten
Franz, Heiko
Guthmann, Florian
Guzman, Carlos A.
Haase, Roland
Hansen, Gesine
Heselich, Valerie
Hübner, Johannes
Koch, Hans Georg
Oberhoff, Carsten
Riese, Peggy
Schild, Ralf
Seeger, Sven
Tchirikov, Michael
Trittel, Stephanie
von Kaisenberg, Constantin
Mikolajczyk, Rafael
author_facet Langer, Susan
Horn, Johannes
Gottschick, Cornelia
Klee, Bianca
Purschke, Oliver
Caputo, Mahrrouz
Dorendorf, Evelyn
Meyer-Schlinkmann, Kristin Maria
Raupach-Rosin, Heike
Karch, André
Rübsamen, Nicole
Aydogdu, Mustafa
Buhles, Matthias
Dressler, Frank
Eberl, Wolfgang
von Koch, Franz Edler
Frambach, Torsten
Franz, Heiko
Guthmann, Florian
Guzman, Carlos A.
Haase, Roland
Hansen, Gesine
Heselich, Valerie
Hübner, Johannes
Koch, Hans Georg
Oberhoff, Carsten
Riese, Peggy
Schild, Ralf
Seeger, Sven
Tchirikov, Michael
Trittel, Stephanie
von Kaisenberg, Constantin
Mikolajczyk, Rafael
author_sort Langer, Susan
collection PubMed
description Acute respiratory infections (ARIs) are the most common childhood illnesses worldwide whereby the reported frequency varies widely, often depending on type of assessment. Symptom diaries are a powerful tool to counteract possible under-reporting, particularly of milder infections, and thus offer the possibility to assess the full burden of ARIs. The following analyses are based on symptom diaries from participants of the German birth cohort study LoewenKIDS. Primary analyses included frequencies of ARIs and specific symptoms. Factors, which might be associated with an increased number of ARIs, were identified using the Poisson regression. A subsample of two hundred eighty-eight participants were included. On average, 13.7 ARIs (SD: 5.2 median: 14.0 IQR: 10–17) were reported in the first two years of life with an average duration of 11 days per episode (SD: 5.8, median: 9.7, IQR: 7–14). The median age for the first ARI episode was 91 days (IQR: 57–128, mean: 107, SD: 84.5). Childcare attendance and having siblings were associated with an increased frequency of ARIs, while exclusive breastfeeding for the first three months was associated with less ARIs, compared to exclusive breastfeeding for a longer period. This study provides detailed insight into the symptom burden of ARIs in German infants.
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spelling pubmed-87815932022-01-22 Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort Langer, Susan Horn, Johannes Gottschick, Cornelia Klee, Bianca Purschke, Oliver Caputo, Mahrrouz Dorendorf, Evelyn Meyer-Schlinkmann, Kristin Maria Raupach-Rosin, Heike Karch, André Rübsamen, Nicole Aydogdu, Mustafa Buhles, Matthias Dressler, Frank Eberl, Wolfgang von Koch, Franz Edler Frambach, Torsten Franz, Heiko Guthmann, Florian Guzman, Carlos A. Haase, Roland Hansen, Gesine Heselich, Valerie Hübner, Johannes Koch, Hans Georg Oberhoff, Carsten Riese, Peggy Schild, Ralf Seeger, Sven Tchirikov, Michael Trittel, Stephanie von Kaisenberg, Constantin Mikolajczyk, Rafael Microorganisms Article Acute respiratory infections (ARIs) are the most common childhood illnesses worldwide whereby the reported frequency varies widely, often depending on type of assessment. Symptom diaries are a powerful tool to counteract possible under-reporting, particularly of milder infections, and thus offer the possibility to assess the full burden of ARIs. The following analyses are based on symptom diaries from participants of the German birth cohort study LoewenKIDS. Primary analyses included frequencies of ARIs and specific symptoms. Factors, which might be associated with an increased number of ARIs, were identified using the Poisson regression. A subsample of two hundred eighty-eight participants were included. On average, 13.7 ARIs (SD: 5.2 median: 14.0 IQR: 10–17) were reported in the first two years of life with an average duration of 11 days per episode (SD: 5.8, median: 9.7, IQR: 7–14). The median age for the first ARI episode was 91 days (IQR: 57–128, mean: 107, SD: 84.5). Childcare attendance and having siblings were associated with an increased frequency of ARIs, while exclusive breastfeeding for the first three months was associated with less ARIs, compared to exclusive breastfeeding for a longer period. This study provides detailed insight into the symptom burden of ARIs in German infants. MDPI 2022-01-05 /pmc/articles/PMC8781593/ /pubmed/35056559 http://dx.doi.org/10.3390/microorganisms10010111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Langer, Susan
Horn, Johannes
Gottschick, Cornelia
Klee, Bianca
Purschke, Oliver
Caputo, Mahrrouz
Dorendorf, Evelyn
Meyer-Schlinkmann, Kristin Maria
Raupach-Rosin, Heike
Karch, André
Rübsamen, Nicole
Aydogdu, Mustafa
Buhles, Matthias
Dressler, Frank
Eberl, Wolfgang
von Koch, Franz Edler
Frambach, Torsten
Franz, Heiko
Guthmann, Florian
Guzman, Carlos A.
Haase, Roland
Hansen, Gesine
Heselich, Valerie
Hübner, Johannes
Koch, Hans Georg
Oberhoff, Carsten
Riese, Peggy
Schild, Ralf
Seeger, Sven
Tchirikov, Michael
Trittel, Stephanie
von Kaisenberg, Constantin
Mikolajczyk, Rafael
Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title_full Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title_fullStr Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title_full_unstemmed Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title_short Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort
title_sort symptom burden and factors associated with acute respiratory infections in the first two years of life—results from the loewenkids cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781593/
https://www.ncbi.nlm.nih.gov/pubmed/35056559
http://dx.doi.org/10.3390/microorganisms10010111
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