Cargando…

CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults

CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Mohamed M., Mirza, Imaduddin, Naquiallah, Dina, Hassan, Chandra, Masrur, Mario, Bianco, Francesco M., Mahmoud, Abeer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781676/
https://www.ncbi.nlm.nih.gov/pubmed/35050217
http://dx.doi.org/10.3390/jcdd9010007
_version_ 1784638135870685184
author Ali, Mohamed M.
Mirza, Imaduddin
Naquiallah, Dina
Hassan, Chandra
Masrur, Mario
Bianco, Francesco M.
Mahmoud, Abeer M.
author_facet Ali, Mohamed M.
Mirza, Imaduddin
Naquiallah, Dina
Hassan, Chandra
Masrur, Mario
Bianco, Francesco M.
Mahmoud, Abeer M.
author_sort Ali, Mohamed M.
collection PubMed
description CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (n = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors.
format Online
Article
Text
id pubmed-8781676
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87816762022-01-22 CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Ali, Mohamed M. Mirza, Imaduddin Naquiallah, Dina Hassan, Chandra Masrur, Mario Bianco, Francesco M. Mahmoud, Abeer M. J Cardiovasc Dev Dis Article CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (n = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors. MDPI 2021-12-28 /pmc/articles/PMC8781676/ /pubmed/35050217 http://dx.doi.org/10.3390/jcdd9010007 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ali, Mohamed M.
Mirza, Imaduddin
Naquiallah, Dina
Hassan, Chandra
Masrur, Mario
Bianco, Francesco M.
Mahmoud, Abeer M.
CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title_full CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title_fullStr CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title_full_unstemmed CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title_short CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
title_sort cd147 levels in blood and adipose tissues correlate with vascular dysfunction in obese diabetic adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781676/
https://www.ncbi.nlm.nih.gov/pubmed/35050217
http://dx.doi.org/10.3390/jcdd9010007
work_keys_str_mv AT alimohamedm cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT mirzaimaduddin cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT naquiallahdina cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT hassanchandra cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT masrurmario cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT biancofrancescom cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults
AT mahmoudabeerm cd147levelsinbloodandadiposetissuescorrelatewithvasculardysfunctioninobesediabeticadults