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Recent Developments in Metabolomics Studies of Endophytic Fungi

Endophytic fungi are microorganisms that colonize living plants’ tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the i...

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Autores principales: Nagarajan, Kashvintha, Ibrahim, Baharudin, Ahmad Bawadikji, Abdulkader, Lim, Jun-Wei, Tong, Woei-Yenn, Leong, Chean-Ring, Khaw, Kooi Yeong, Tan, Wen-Nee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781825/
https://www.ncbi.nlm.nih.gov/pubmed/35049968
http://dx.doi.org/10.3390/jof8010028
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author Nagarajan, Kashvintha
Ibrahim, Baharudin
Ahmad Bawadikji, Abdulkader
Lim, Jun-Wei
Tong, Woei-Yenn
Leong, Chean-Ring
Khaw, Kooi Yeong
Tan, Wen-Nee
author_facet Nagarajan, Kashvintha
Ibrahim, Baharudin
Ahmad Bawadikji, Abdulkader
Lim, Jun-Wei
Tong, Woei-Yenn
Leong, Chean-Ring
Khaw, Kooi Yeong
Tan, Wen-Nee
author_sort Nagarajan, Kashvintha
collection PubMed
description Endophytic fungi are microorganisms that colonize living plants’ tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the increasing trends in human health problems and diseases have escalated the search for bioactive metabolites from endophytic fungi. The conventional bioassay-guided study is known as laborious due to chemical complexity. Thus, metabolomics studies have attracted extensive research interest owing to their potential in dealing with a vast number of metabolites. Metabolomics coupled with advanced analytical tools provides a comprehensive insight into systems biology. Despite its wide scientific attention, endophytic fungi metabolomics are relatively unexploited. This review highlights the recent developments in metabolomics studies of endophytic fungi in obtaining the global metabolites picture.
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spelling pubmed-87818252022-01-22 Recent Developments in Metabolomics Studies of Endophytic Fungi Nagarajan, Kashvintha Ibrahim, Baharudin Ahmad Bawadikji, Abdulkader Lim, Jun-Wei Tong, Woei-Yenn Leong, Chean-Ring Khaw, Kooi Yeong Tan, Wen-Nee J Fungi (Basel) Review Endophytic fungi are microorganisms that colonize living plants’ tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the increasing trends in human health problems and diseases have escalated the search for bioactive metabolites from endophytic fungi. The conventional bioassay-guided study is known as laborious due to chemical complexity. Thus, metabolomics studies have attracted extensive research interest owing to their potential in dealing with a vast number of metabolites. Metabolomics coupled with advanced analytical tools provides a comprehensive insight into systems biology. Despite its wide scientific attention, endophytic fungi metabolomics are relatively unexploited. This review highlights the recent developments in metabolomics studies of endophytic fungi in obtaining the global metabolites picture. MDPI 2021-12-29 /pmc/articles/PMC8781825/ /pubmed/35049968 http://dx.doi.org/10.3390/jof8010028 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nagarajan, Kashvintha
Ibrahim, Baharudin
Ahmad Bawadikji, Abdulkader
Lim, Jun-Wei
Tong, Woei-Yenn
Leong, Chean-Ring
Khaw, Kooi Yeong
Tan, Wen-Nee
Recent Developments in Metabolomics Studies of Endophytic Fungi
title Recent Developments in Metabolomics Studies of Endophytic Fungi
title_full Recent Developments in Metabolomics Studies of Endophytic Fungi
title_fullStr Recent Developments in Metabolomics Studies of Endophytic Fungi
title_full_unstemmed Recent Developments in Metabolomics Studies of Endophytic Fungi
title_short Recent Developments in Metabolomics Studies of Endophytic Fungi
title_sort recent developments in metabolomics studies of endophytic fungi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781825/
https://www.ncbi.nlm.nih.gov/pubmed/35049968
http://dx.doi.org/10.3390/jof8010028
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