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Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781846/ https://www.ncbi.nlm.nih.gov/pubmed/35056951 http://dx.doi.org/10.3390/pharmaceutics14010056 |
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author | Noureddine, Achraf Paffett, Michael L. Franco, Stefan Chan, Alfonso E. Pallikkuth, Sandeep Lidke, Keith Serda, Rita E. |
author_facet | Noureddine, Achraf Paffett, Michael L. Franco, Stefan Chan, Alfonso E. Pallikkuth, Sandeep Lidke, Keith Serda, Rita E. |
author_sort | Noureddine, Achraf |
collection | PubMed |
description | This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision. |
format | Online Article Text |
id | pubmed-8781846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87818462022-01-22 Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways Noureddine, Achraf Paffett, Michael L. Franco, Stefan Chan, Alfonso E. Pallikkuth, Sandeep Lidke, Keith Serda, Rita E. Pharmaceutics Article This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision. MDPI 2021-12-27 /pmc/articles/PMC8781846/ /pubmed/35056951 http://dx.doi.org/10.3390/pharmaceutics14010056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noureddine, Achraf Paffett, Michael L. Franco, Stefan Chan, Alfonso E. Pallikkuth, Sandeep Lidke, Keith Serda, Rita E. Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title | Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title_full | Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title_fullStr | Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title_full_unstemmed | Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title_short | Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways |
title_sort | endolysosomal mesoporous silica nanoparticle trafficking along microtubular highways |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781846/ https://www.ncbi.nlm.nih.gov/pubmed/35056951 http://dx.doi.org/10.3390/pharmaceutics14010056 |
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