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Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways

This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell c...

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Detalles Bibliográficos
Autores principales: Noureddine, Achraf, Paffett, Michael L., Franco, Stefan, Chan, Alfonso E., Pallikkuth, Sandeep, Lidke, Keith, Serda, Rita E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781846/
https://www.ncbi.nlm.nih.gov/pubmed/35056951
http://dx.doi.org/10.3390/pharmaceutics14010056
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author Noureddine, Achraf
Paffett, Michael L.
Franco, Stefan
Chan, Alfonso E.
Pallikkuth, Sandeep
Lidke, Keith
Serda, Rita E.
author_facet Noureddine, Achraf
Paffett, Michael L.
Franco, Stefan
Chan, Alfonso E.
Pallikkuth, Sandeep
Lidke, Keith
Serda, Rita E.
author_sort Noureddine, Achraf
collection PubMed
description This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision.
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spelling pubmed-87818462022-01-22 Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways Noureddine, Achraf Paffett, Michael L. Franco, Stefan Chan, Alfonso E. Pallikkuth, Sandeep Lidke, Keith Serda, Rita E. Pharmaceutics Article This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision. MDPI 2021-12-27 /pmc/articles/PMC8781846/ /pubmed/35056951 http://dx.doi.org/10.3390/pharmaceutics14010056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noureddine, Achraf
Paffett, Michael L.
Franco, Stefan
Chan, Alfonso E.
Pallikkuth, Sandeep
Lidke, Keith
Serda, Rita E.
Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title_full Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title_fullStr Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title_full_unstemmed Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title_short Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
title_sort endolysosomal mesoporous silica nanoparticle trafficking along microtubular highways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781846/
https://www.ncbi.nlm.nih.gov/pubmed/35056951
http://dx.doi.org/10.3390/pharmaceutics14010056
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