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The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province

Background and Objectives: Studies suggest that vitamin D is involved in the development of type 2 diabetes mellitus (T2DM) and influences serum lipids levels, while lipid disorders are also closely related to T2DM. This study attempts to explore the complex relationship of serum 25(OH)D(3), serum l...

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Autores principales: Zhang, Mimi, Yu, Fei, Xue, Yuan, Song, Lulu, Du, Mengsi, Li, Xing, Li, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781849/
https://www.ncbi.nlm.nih.gov/pubmed/35056393
http://dx.doi.org/10.3390/medicina58010085
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author Zhang, Mimi
Yu, Fei
Xue, Yuan
Song, Lulu
Du, Mengsi
Li, Xing
Li, Wenjie
author_facet Zhang, Mimi
Yu, Fei
Xue, Yuan
Song, Lulu
Du, Mengsi
Li, Xing
Li, Wenjie
author_sort Zhang, Mimi
collection PubMed
description Background and Objectives: Studies suggest that vitamin D is involved in the development of type 2 diabetes mellitus (T2DM) and influences serum lipids levels, while lipid disorders are also closely related to T2DM. This study attempts to explore the complex relationship of serum 25(OH)D(3), serum lipids, and T2DM among Chinese population. Materials and Methods: A cross-sectional study was carried out among 2326 subjects. The chi-square (χ(2)) test was applied to compare the prevalence of T2DM or dyslipidemia between two serum 25(OH)D(3) levels. Linear regression was applied to analyze the correlation between serum lipids and 25(OH)D(3) contents. Univariate and logistic analysis were used to explore the relationship between two lipid levels and T2DM. Mediation analysis was used to explore whether serum lipids mediate the relationship between two serum 25(OH)D(3) levels and T2DM. Results: Compared to subjects with 25(OH)D(3) ≥ 30 ng/mL, subjects with 25(OH)D(3) < 30 ng/mL were higher in the prevalence of T2DM. The occurrences of high TG and low HDL-C were significantly higher in vitamin D deficiency and insufficiency than those in vitamin D sufficiency. Serum 25(OH)D(3) content showed a reverse correlation with TC, TG, and LDL-C, but positive correlation with HDL-C. The odds ratios (ORs) (95% confidence intervals, 95%CI) of T2DM by comparing TG ≥ 2.26 mmol/L vs. TG < 2.26 mmol/L and HDL-C < 1.04 mmol/L vs. HDL-C ≥ 1.04 mmol/L in all participants were 2.48 (1.94–3.18) and 1.37 (1.07–1.75), respectively. Serum TG or HDL-C level partially mediated the relationship between two 25(OH)D(3) level and T2DM. Conclusions: Serum 25(OH)D(3) < 30 ng/mL seems to be associated with T2DM or dyslipidemia (high TG and low HDL-C) in our study, but there is still no proof of a cause–effect relationship. Moreover, serum TG or HDL-C level partially mediated the relationship between 25(OH)D(3) levels and T2DM.
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spelling pubmed-87818492022-01-22 The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province Zhang, Mimi Yu, Fei Xue, Yuan Song, Lulu Du, Mengsi Li, Xing Li, Wenjie Medicina (Kaunas) Article Background and Objectives: Studies suggest that vitamin D is involved in the development of type 2 diabetes mellitus (T2DM) and influences serum lipids levels, while lipid disorders are also closely related to T2DM. This study attempts to explore the complex relationship of serum 25(OH)D(3), serum lipids, and T2DM among Chinese population. Materials and Methods: A cross-sectional study was carried out among 2326 subjects. The chi-square (χ(2)) test was applied to compare the prevalence of T2DM or dyslipidemia between two serum 25(OH)D(3) levels. Linear regression was applied to analyze the correlation between serum lipids and 25(OH)D(3) contents. Univariate and logistic analysis were used to explore the relationship between two lipid levels and T2DM. Mediation analysis was used to explore whether serum lipids mediate the relationship between two serum 25(OH)D(3) levels and T2DM. Results: Compared to subjects with 25(OH)D(3) ≥ 30 ng/mL, subjects with 25(OH)D(3) < 30 ng/mL were higher in the prevalence of T2DM. The occurrences of high TG and low HDL-C were significantly higher in vitamin D deficiency and insufficiency than those in vitamin D sufficiency. Serum 25(OH)D(3) content showed a reverse correlation with TC, TG, and LDL-C, but positive correlation with HDL-C. The odds ratios (ORs) (95% confidence intervals, 95%CI) of T2DM by comparing TG ≥ 2.26 mmol/L vs. TG < 2.26 mmol/L and HDL-C < 1.04 mmol/L vs. HDL-C ≥ 1.04 mmol/L in all participants were 2.48 (1.94–3.18) and 1.37 (1.07–1.75), respectively. Serum TG or HDL-C level partially mediated the relationship between two 25(OH)D(3) level and T2DM. Conclusions: Serum 25(OH)D(3) < 30 ng/mL seems to be associated with T2DM or dyslipidemia (high TG and low HDL-C) in our study, but there is still no proof of a cause–effect relationship. Moreover, serum TG or HDL-C level partially mediated the relationship between 25(OH)D(3) levels and T2DM. MDPI 2022-01-06 /pmc/articles/PMC8781849/ /pubmed/35056393 http://dx.doi.org/10.3390/medicina58010085 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Mimi
Yu, Fei
Xue, Yuan
Song, Lulu
Du, Mengsi
Li, Xing
Li, Wenjie
The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title_full The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title_fullStr The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title_full_unstemmed The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title_short The Relationship of 25(OH)D(3) with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province
title_sort relationship of 25(oh)d(3) with diabetes mellitus and the mediation effect of lipid profile in chinese rural population of henan province
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781849/
https://www.ncbi.nlm.nih.gov/pubmed/35056393
http://dx.doi.org/10.3390/medicina58010085
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