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The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond
The survival of eukaryotic organisms during environmental changes is largely dependent on the adaptive responses elicited by signal transduction cascades, including those regulated by the Mitogen-Activated Protein Kinase (MAPK) pathways. The Cell Integrity Pathway (CIP), one of the three MAPK pathwa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781887/ https://www.ncbi.nlm.nih.gov/pubmed/35049972 http://dx.doi.org/10.3390/jof8010032 |
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author | Cansado, José Soto, Teresa Franco, Alejandro Vicente-Soler, Jero Madrid, Marisa |
author_facet | Cansado, José Soto, Teresa Franco, Alejandro Vicente-Soler, Jero Madrid, Marisa |
author_sort | Cansado, José |
collection | PubMed |
description | The survival of eukaryotic organisms during environmental changes is largely dependent on the adaptive responses elicited by signal transduction cascades, including those regulated by the Mitogen-Activated Protein Kinase (MAPK) pathways. The Cell Integrity Pathway (CIP), one of the three MAPK pathways found in the simple eukaryote fission of yeast Schizosaccharomyces pombe, shows strong homology with mammalian Extracellular signal-Regulated Kinases (ERKs). Remarkably, studies over the last few decades have gradually positioned the CIP as a multi-faceted pathway that impacts multiple functional aspects of the fission yeast life cycle during unperturbed growth and in response to stress. They include the control of mRNA-stability through RNA binding proteins, regulation of calcium homeostasis, and modulation of cell wall integrity and cytokinesis. Moreover, distinct evidence has disclosed the existence of sophisticated interplay between the CIP and other environmentally regulated pathways, including Stress-Activated MAP Kinase signaling (SAPK) and the Target of Rapamycin (TOR). In this review we present a current overview of the organization and underlying regulatory mechanisms of the CIP in S. pombe, describe its most prominent functions, and discuss possible targets of and roles for this pathway. The evolutionary conservation of CIP signaling in the dimorphic fission yeast S. japonicus will also be addressed. |
format | Online Article Text |
id | pubmed-8781887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87818872022-01-22 The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond Cansado, José Soto, Teresa Franco, Alejandro Vicente-Soler, Jero Madrid, Marisa J Fungi (Basel) Review The survival of eukaryotic organisms during environmental changes is largely dependent on the adaptive responses elicited by signal transduction cascades, including those regulated by the Mitogen-Activated Protein Kinase (MAPK) pathways. The Cell Integrity Pathway (CIP), one of the three MAPK pathways found in the simple eukaryote fission of yeast Schizosaccharomyces pombe, shows strong homology with mammalian Extracellular signal-Regulated Kinases (ERKs). Remarkably, studies over the last few decades have gradually positioned the CIP as a multi-faceted pathway that impacts multiple functional aspects of the fission yeast life cycle during unperturbed growth and in response to stress. They include the control of mRNA-stability through RNA binding proteins, regulation of calcium homeostasis, and modulation of cell wall integrity and cytokinesis. Moreover, distinct evidence has disclosed the existence of sophisticated interplay between the CIP and other environmentally regulated pathways, including Stress-Activated MAP Kinase signaling (SAPK) and the Target of Rapamycin (TOR). In this review we present a current overview of the organization and underlying regulatory mechanisms of the CIP in S. pombe, describe its most prominent functions, and discuss possible targets of and roles for this pathway. The evolutionary conservation of CIP signaling in the dimorphic fission yeast S. japonicus will also be addressed. MDPI 2021-12-30 /pmc/articles/PMC8781887/ /pubmed/35049972 http://dx.doi.org/10.3390/jof8010032 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cansado, José Soto, Teresa Franco, Alejandro Vicente-Soler, Jero Madrid, Marisa The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title | The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title_full | The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title_fullStr | The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title_full_unstemmed | The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title_short | The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond |
title_sort | fission yeast cell integrity pathway: a functional hub for cell survival upon stress and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781887/ https://www.ncbi.nlm.nih.gov/pubmed/35049972 http://dx.doi.org/10.3390/jof8010032 |
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