The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly inf...

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Detalles Bibliográficos
Autores principales: Miyashiro, Denis, Souza, Bruno de Castro e, Torrealba, Marina Passos, Manfrere, Kelly Cristina Gomes, Sato, Maria Notomi, Sanches, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781892/
https://www.ncbi.nlm.nih.gov/pubmed/35055124
http://dx.doi.org/10.3390/ijms23020936
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author Miyashiro, Denis
Souza, Bruno de Castro e
Torrealba, Marina Passos
Manfrere, Kelly Cristina Gomes
Sato, Maria Notomi
Sanches, José Antonio
author_facet Miyashiro, Denis
Souza, Bruno de Castro e
Torrealba, Marina Passos
Manfrere, Kelly Cristina Gomes
Sato, Maria Notomi
Sanches, José Antonio
author_sort Miyashiro, Denis
collection PubMed
description Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.
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spelling pubmed-87818922022-01-22 The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome Miyashiro, Denis Souza, Bruno de Castro e Torrealba, Marina Passos Manfrere, Kelly Cristina Gomes Sato, Maria Notomi Sanches, José Antonio Int J Mol Sci Review Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment. MDPI 2022-01-15 /pmc/articles/PMC8781892/ /pubmed/35055124 http://dx.doi.org/10.3390/ijms23020936 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miyashiro, Denis
Souza, Bruno de Castro e
Torrealba, Marina Passos
Manfrere, Kelly Cristina Gomes
Sato, Maria Notomi
Sanches, José Antonio
The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title_full The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title_fullStr The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title_full_unstemmed The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title_short The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
title_sort role of tumor microenvironment in the pathogenesis of sézary syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781892/
https://www.ncbi.nlm.nih.gov/pubmed/35055124
http://dx.doi.org/10.3390/ijms23020936
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