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Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021

Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult. Although a high number of EV-D68 infections we...

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Autores principales: Tedcastle, Alison, Wilton, Thomas, Pegg, Elaine, Klapsa, Dimitra, Bujaki, Erika, Mate, Ryan, Fritzsche, Martin, Majumdar, Manasi, Martin, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781944/
https://www.ncbi.nlm.nih.gov/pubmed/35062346
http://dx.doi.org/10.3390/v14010143
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author Tedcastle, Alison
Wilton, Thomas
Pegg, Elaine
Klapsa, Dimitra
Bujaki, Erika
Mate, Ryan
Fritzsche, Martin
Majumdar, Manasi
Martin, Javier
author_facet Tedcastle, Alison
Wilton, Thomas
Pegg, Elaine
Klapsa, Dimitra
Bujaki, Erika
Mate, Ryan
Fritzsche, Martin
Majumdar, Manasi
Martin, Javier
author_sort Tedcastle, Alison
collection PubMed
description Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult. Although a high number of EV-D68 infections were expected in 2020 based on the EV-D68′s known biannual circulation patterns, no apparent increase in EV-D68 detections or AFM cases was observed during 2020. We describe an upsurge of EV-D68 detections in wastewater samples from the United Kingdom between July and November 2021 mirroring the recently reported rise in EV-D68 detections in clinical samples from various European countries. We provide the first publicly available 2021 EV-D68 sequences showing co-circulation of EV-D68 strains from genetic clade D and sub-clade B3 as in previous years. Our results show the value of environmental surveillance (ES) for the early detection of circulating and clinically relevant human viruses. The use of a next-generation sequencing (NGS) approach helped us to estimate the prevalence of EV-D68 viruses among EV strains from other EV serotypes and to detect EV-D68 minor variants. The utility of ES at reducing gaps in virus surveillance for EV-D68 and the possible impact of nonpharmaceutical interventions introduced to control the COVID-19 pandemic on EV-D68 transmission dynamics are discussed.
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spelling pubmed-87819442022-01-22 Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021 Tedcastle, Alison Wilton, Thomas Pegg, Elaine Klapsa, Dimitra Bujaki, Erika Mate, Ryan Fritzsche, Martin Majumdar, Manasi Martin, Javier Viruses Brief Report Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult. Although a high number of EV-D68 infections were expected in 2020 based on the EV-D68′s known biannual circulation patterns, no apparent increase in EV-D68 detections or AFM cases was observed during 2020. We describe an upsurge of EV-D68 detections in wastewater samples from the United Kingdom between July and November 2021 mirroring the recently reported rise in EV-D68 detections in clinical samples from various European countries. We provide the first publicly available 2021 EV-D68 sequences showing co-circulation of EV-D68 strains from genetic clade D and sub-clade B3 as in previous years. Our results show the value of environmental surveillance (ES) for the early detection of circulating and clinically relevant human viruses. The use of a next-generation sequencing (NGS) approach helped us to estimate the prevalence of EV-D68 viruses among EV strains from other EV serotypes and to detect EV-D68 minor variants. The utility of ES at reducing gaps in virus surveillance for EV-D68 and the possible impact of nonpharmaceutical interventions introduced to control the COVID-19 pandemic on EV-D68 transmission dynamics are discussed. MDPI 2022-01-13 /pmc/articles/PMC8781944/ /pubmed/35062346 http://dx.doi.org/10.3390/v14010143 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Tedcastle, Alison
Wilton, Thomas
Pegg, Elaine
Klapsa, Dimitra
Bujaki, Erika
Mate, Ryan
Fritzsche, Martin
Majumdar, Manasi
Martin, Javier
Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title_full Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title_fullStr Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title_full_unstemmed Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title_short Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
title_sort detection of enterovirus d68 in wastewater samples from the uk between july and november 2021
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781944/
https://www.ncbi.nlm.nih.gov/pubmed/35062346
http://dx.doi.org/10.3390/v14010143
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