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Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers

Melt electrospinning is a polymer processing technology for the manufacture of microfibers and nanofibers. Additives are required to reduce the melt viscosity and increase its conductivity in order to minimize the fiber diameter, and can also impart additional beneficial properties. We investigated...

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Autores principales: Ostheller, Maike-Elisa, Abdelgawad, Abdelrahman M., Balakrishnan, Naveen Kumar, Hassanin, Ahmed H., Groten, Robert, Seide, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781972/
https://www.ncbi.nlm.nih.gov/pubmed/35055300
http://dx.doi.org/10.3390/nano12020283
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author Ostheller, Maike-Elisa
Abdelgawad, Abdelrahman M.
Balakrishnan, Naveen Kumar
Hassanin, Ahmed H.
Groten, Robert
Seide, Gunnar
author_facet Ostheller, Maike-Elisa
Abdelgawad, Abdelrahman M.
Balakrishnan, Naveen Kumar
Hassanin, Ahmed H.
Groten, Robert
Seide, Gunnar
author_sort Ostheller, Maike-Elisa
collection PubMed
description Melt electrospinning is a polymer processing technology for the manufacture of microfibers and nanofibers. Additives are required to reduce the melt viscosity and increase its conductivity in order to minimize the fiber diameter, and can also impart additional beneficial properties. We investigated the preparation of polybutylene succinate (PBS) microfibers incorporating different weight percentages of two multifunctional additives (the organic dye curcumin and inorganic silver nanoparticles) using a single-nozzle laboratory-scale device. We determined the influence of these additives on the polymer melt viscosity, electrical conductivity, degradation profile, thermal behavior, fiber diameter, and antibacterial activity. The formation of a Taylor cone followed by continuous fiber deposition was observed for compounds containing up to 3% (w/w) silver nanoparticles and up to 10% (w/w) curcumin, the latter achieving the minimum average fiber diameter of 12.57 µm. Both additives reduced the viscosity and increased the electrical conductivity of the PBS melt, and also retained their specific antibacterial properties when compounded and spun into fibers. This is the first report describing the effect of curcumin and silver nanoparticles on the properties of PBS fibers manufactured using a single-nozzle melt-electrospinning device. Our results provide the basis to develop environmentally benign antibacterial melt-electrospun PBS fibers for biomedical applications.
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spelling pubmed-87819722022-01-22 Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers Ostheller, Maike-Elisa Abdelgawad, Abdelrahman M. Balakrishnan, Naveen Kumar Hassanin, Ahmed H. Groten, Robert Seide, Gunnar Nanomaterials (Basel) Article Melt electrospinning is a polymer processing technology for the manufacture of microfibers and nanofibers. Additives are required to reduce the melt viscosity and increase its conductivity in order to minimize the fiber diameter, and can also impart additional beneficial properties. We investigated the preparation of polybutylene succinate (PBS) microfibers incorporating different weight percentages of two multifunctional additives (the organic dye curcumin and inorganic silver nanoparticles) using a single-nozzle laboratory-scale device. We determined the influence of these additives on the polymer melt viscosity, electrical conductivity, degradation profile, thermal behavior, fiber diameter, and antibacterial activity. The formation of a Taylor cone followed by continuous fiber deposition was observed for compounds containing up to 3% (w/w) silver nanoparticles and up to 10% (w/w) curcumin, the latter achieving the minimum average fiber diameter of 12.57 µm. Both additives reduced the viscosity and increased the electrical conductivity of the PBS melt, and also retained their specific antibacterial properties when compounded and spun into fibers. This is the first report describing the effect of curcumin and silver nanoparticles on the properties of PBS fibers manufactured using a single-nozzle melt-electrospinning device. Our results provide the basis to develop environmentally benign antibacterial melt-electrospun PBS fibers for biomedical applications. MDPI 2022-01-17 /pmc/articles/PMC8781972/ /pubmed/35055300 http://dx.doi.org/10.3390/nano12020283 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ostheller, Maike-Elisa
Abdelgawad, Abdelrahman M.
Balakrishnan, Naveen Kumar
Hassanin, Ahmed H.
Groten, Robert
Seide, Gunnar
Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title_full Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title_fullStr Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title_full_unstemmed Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title_short Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers
title_sort curcumin and silver doping enhance the spinnability and antibacterial activity of melt-electrospun polybutylene succinate fibers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781972/
https://www.ncbi.nlm.nih.gov/pubmed/35055300
http://dx.doi.org/10.3390/nano12020283
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