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Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host
Nutrient uptake is essential for cellular life and the capacity to perceive extracellular nutrients is critical for coordinating their uptake and metabolism. Commensal fungal pathogens, e.g., Candida albicans, have evolved in close association with human hosts and are well-adapted to using diverse n...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781990/ https://www.ncbi.nlm.nih.gov/pubmed/35055954 http://dx.doi.org/10.3390/pathogens11010005 |
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author | Silao, Fitz Gerald S. Ljungdahl, Per O. |
author_facet | Silao, Fitz Gerald S. Ljungdahl, Per O. |
author_sort | Silao, Fitz Gerald S. |
collection | PubMed |
description | Nutrient uptake is essential for cellular life and the capacity to perceive extracellular nutrients is critical for coordinating their uptake and metabolism. Commensal fungal pathogens, e.g., Candida albicans, have evolved in close association with human hosts and are well-adapted to using diverse nutrients found in discrete host niches. Human cells that cannot synthesize all amino acids require the uptake of the “essential amino acids” to remain viable. Consistently, high levels of amino acids circulate in the blood. Host proteins are rich sources of amino acids but their use depends on proteases to cleave them into smaller peptides and free amino acids. C. albicans responds to extracellular amino acids by pleiotropically enhancing their uptake and derive energy from their catabolism to power opportunistic virulent growth. Studies using Saccharomyces cerevisiae have established paradigms to understand metabolic processes in C. albicans; however, fundamental differences exist. The advent of CRISPR/Cas9-based methods facilitate genetic analysis in C. albicans, and state-of-the-art molecular biological techniques are being applied to directly examine growth requirements in vivo and in situ in infected hosts. The combination of divergent approaches can illuminate the biological roles of individual cellular components. Here we discuss recent findings regarding nutrient sensing with a focus on amino acid uptake and metabolism, processes that underlie the virulence of C. albicans. |
format | Online Article Text |
id | pubmed-8781990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87819902022-01-22 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host Silao, Fitz Gerald S. Ljungdahl, Per O. Pathogens Review Nutrient uptake is essential for cellular life and the capacity to perceive extracellular nutrients is critical for coordinating their uptake and metabolism. Commensal fungal pathogens, e.g., Candida albicans, have evolved in close association with human hosts and are well-adapted to using diverse nutrients found in discrete host niches. Human cells that cannot synthesize all amino acids require the uptake of the “essential amino acids” to remain viable. Consistently, high levels of amino acids circulate in the blood. Host proteins are rich sources of amino acids but their use depends on proteases to cleave them into smaller peptides and free amino acids. C. albicans responds to extracellular amino acids by pleiotropically enhancing their uptake and derive energy from their catabolism to power opportunistic virulent growth. Studies using Saccharomyces cerevisiae have established paradigms to understand metabolic processes in C. albicans; however, fundamental differences exist. The advent of CRISPR/Cas9-based methods facilitate genetic analysis in C. albicans, and state-of-the-art molecular biological techniques are being applied to directly examine growth requirements in vivo and in situ in infected hosts. The combination of divergent approaches can illuminate the biological roles of individual cellular components. Here we discuss recent findings regarding nutrient sensing with a focus on amino acid uptake and metabolism, processes that underlie the virulence of C. albicans. MDPI 2021-12-22 /pmc/articles/PMC8781990/ /pubmed/35055954 http://dx.doi.org/10.3390/pathogens11010005 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silao, Fitz Gerald S. Ljungdahl, Per O. Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title | Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title_full | Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title_fullStr | Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title_full_unstemmed | Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title_short | Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host |
title_sort | amino acid sensing and assimilation by the fungal pathogen candida albicans in the human host |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781990/ https://www.ncbi.nlm.nih.gov/pubmed/35055954 http://dx.doi.org/10.3390/pathogens11010005 |
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