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Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level
Hepatic steatosis is characterized by triglyceride accumulation within hepatocytes in response to a high calorie intake, and it may be related to intestinal microbiota disturbances. The prebiotic inulin is a naturally occurring polysaccharide with a high dietary fiber content. Here, we evaluate the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782000/ https://www.ncbi.nlm.nih.gov/pubmed/35055177 http://dx.doi.org/10.3390/ijms23020991 |
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author | Pérez-Monter, Carlos Álvarez-Arce, Alejandro Nuño-Lambarri, Natalia Escalona-Nández, Ivonne Juárez-Hernández, Eva Chávez-Tapia, Norberto C. Uribe, Misael Barbero-Becerra, Varenka J. |
author_facet | Pérez-Monter, Carlos Álvarez-Arce, Alejandro Nuño-Lambarri, Natalia Escalona-Nández, Ivonne Juárez-Hernández, Eva Chávez-Tapia, Norberto C. Uribe, Misael Barbero-Becerra, Varenka J. |
author_sort | Pérez-Monter, Carlos |
collection | PubMed |
description | Hepatic steatosis is characterized by triglyceride accumulation within hepatocytes in response to a high calorie intake, and it may be related to intestinal microbiota disturbances. The prebiotic inulin is a naturally occurring polysaccharide with a high dietary fiber content. Here, we evaluate the effect of inulin on the intestinal microbiota in a non-alcoholic fatty liver disease model. Mice exposed to a standard rodent diet or a fat-enriched diet, were supplemented or not, with inulin. Liver histology was evaluated with oil red O and H&E staining and the intestinal microbiota was determined in mice fecal samples by 16S rRNA sequencing. Inulin treatment effectively prevents liver steatosis in the fat-enriched diet group. We also observed that inulin re-shaped the intestinal microbiota at the phylum level, were Verrucomicrobia genus significantly increased in the fat-diet group; specifically, we observed that Akkermansia muciniphila increased by 5-fold with inulin supplementation. The family Prevotellaceae was also significantly increased in the fat-diet group. Overall, we propose that inulin supplementation in liver steatosis-affected animals, promotes a remodeling in the intestinal microbiota composition, which might regulate lipid metabolism, thus contributing to tackling liver steatosis. |
format | Online Article Text |
id | pubmed-8782000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87820002022-01-22 Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level Pérez-Monter, Carlos Álvarez-Arce, Alejandro Nuño-Lambarri, Natalia Escalona-Nández, Ivonne Juárez-Hernández, Eva Chávez-Tapia, Norberto C. Uribe, Misael Barbero-Becerra, Varenka J. Int J Mol Sci Article Hepatic steatosis is characterized by triglyceride accumulation within hepatocytes in response to a high calorie intake, and it may be related to intestinal microbiota disturbances. The prebiotic inulin is a naturally occurring polysaccharide with a high dietary fiber content. Here, we evaluate the effect of inulin on the intestinal microbiota in a non-alcoholic fatty liver disease model. Mice exposed to a standard rodent diet or a fat-enriched diet, were supplemented or not, with inulin. Liver histology was evaluated with oil red O and H&E staining and the intestinal microbiota was determined in mice fecal samples by 16S rRNA sequencing. Inulin treatment effectively prevents liver steatosis in the fat-enriched diet group. We also observed that inulin re-shaped the intestinal microbiota at the phylum level, were Verrucomicrobia genus significantly increased in the fat-diet group; specifically, we observed that Akkermansia muciniphila increased by 5-fold with inulin supplementation. The family Prevotellaceae was also significantly increased in the fat-diet group. Overall, we propose that inulin supplementation in liver steatosis-affected animals, promotes a remodeling in the intestinal microbiota composition, which might regulate lipid metabolism, thus contributing to tackling liver steatosis. MDPI 2022-01-17 /pmc/articles/PMC8782000/ /pubmed/35055177 http://dx.doi.org/10.3390/ijms23020991 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pérez-Monter, Carlos Álvarez-Arce, Alejandro Nuño-Lambarri, Natalia Escalona-Nández, Ivonne Juárez-Hernández, Eva Chávez-Tapia, Norberto C. Uribe, Misael Barbero-Becerra, Varenka J. Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title | Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title_full | Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title_fullStr | Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title_full_unstemmed | Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title_short | Inulin Improves Diet-Induced Hepatic Steatosis and Increases Intestinal Akkermansia Genus Level |
title_sort | inulin improves diet-induced hepatic steatosis and increases intestinal akkermansia genus level |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782000/ https://www.ncbi.nlm.nih.gov/pubmed/35055177 http://dx.doi.org/10.3390/ijms23020991 |
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