Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was evaluated against t...

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Detalles Bibliográficos
Autores principales: de Araújo, Rodrigo Santos Aquino, Carmo, Julianderson de Oliveira dos Santos, de Omena Silva, Simone Lara, Costa da Silva, Camila Radelley Azevedo, Souza, Tayhana Priscila Medeiros, de Mélo, Natália Barbosa, Bourguignon, Jean-Jacques, Schmitt, Martine, de Aquino, Thiago Mendonça, Rodarte, Renato Santos, de Moura, Ricardo Olímpio, Barbosa Filho, José Maria, Barreto, Emiliano, Mendonça-Junior, Francisco Jaime Bezerra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782015/
https://www.ncbi.nlm.nih.gov/pubmed/35056161
http://dx.doi.org/10.3390/ph15010104

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