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Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)

Carnitine deficiency is prevalent in patients undergoing hemodialysis, and it could result in lowered muscle strength. So far, the effect of treatment with levocarnitine on lower limb muscle strength has not been well described. This observational study examined the association between treatment wit...

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Autores principales: Matsufuji, Shota, Shoji, Tetsuo, Lee, Suhye, Yamaguchi, Masao, Nishimura, Mari, Tsujimoto, Yoshihiro, Nakatani, Shinya, Morioka, Tomoaki, Mori, Katsuhito, Emoto, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782050/
https://www.ncbi.nlm.nih.gov/pubmed/35057527
http://dx.doi.org/10.3390/nu14020343
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author Matsufuji, Shota
Shoji, Tetsuo
Lee, Suhye
Yamaguchi, Masao
Nishimura, Mari
Tsujimoto, Yoshihiro
Nakatani, Shinya
Morioka, Tomoaki
Mori, Katsuhito
Emoto, Masanori
author_facet Matsufuji, Shota
Shoji, Tetsuo
Lee, Suhye
Yamaguchi, Masao
Nishimura, Mari
Tsujimoto, Yoshihiro
Nakatani, Shinya
Morioka, Tomoaki
Mori, Katsuhito
Emoto, Masanori
author_sort Matsufuji, Shota
collection PubMed
description Carnitine deficiency is prevalent in patients undergoing hemodialysis, and it could result in lowered muscle strength. So far, the effect of treatment with levocarnitine on lower limb muscle strength has not been well described. This observational study examined the association between treatment with levocarnitine with the change in knee extensor strength (KES) in hemodialysis patients. Eligible patients were selected from the participants enrolled in a prospective cohort study for whom muscle strength was measured annually. We identified 104 eligible patients for this analysis. During the one-year period between 2014 to 2015, 67 patients were treated with intravenous levocarnitine (1000 mg per shot, thrice weekly), whereas 37 patients were not. The change in KES was significantly higher (p = 0.01) in the carnitine group [0.02 (0.01–0.04) kgf/kg] as compared to the non-carnitine group [−0.02 (−0.04 to 0.01) kgf/kg]. Multivariable-adjusted regression analysis showed the positive association between the change in KES and the treatment with levocarnitine remained significant after adjustment for the baseline KES and other potential confounders. Thus, treatment with intravenous levocarnitine was independently and positively associated with the change in KES among hemodialysis patients. Further clinical trials are needed to provide more solid evidence.
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spelling pubmed-87820502022-01-22 Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS) Matsufuji, Shota Shoji, Tetsuo Lee, Suhye Yamaguchi, Masao Nishimura, Mari Tsujimoto, Yoshihiro Nakatani, Shinya Morioka, Tomoaki Mori, Katsuhito Emoto, Masanori Nutrients Article Carnitine deficiency is prevalent in patients undergoing hemodialysis, and it could result in lowered muscle strength. So far, the effect of treatment with levocarnitine on lower limb muscle strength has not been well described. This observational study examined the association between treatment with levocarnitine with the change in knee extensor strength (KES) in hemodialysis patients. Eligible patients were selected from the participants enrolled in a prospective cohort study for whom muscle strength was measured annually. We identified 104 eligible patients for this analysis. During the one-year period between 2014 to 2015, 67 patients were treated with intravenous levocarnitine (1000 mg per shot, thrice weekly), whereas 37 patients were not. The change in KES was significantly higher (p = 0.01) in the carnitine group [0.02 (0.01–0.04) kgf/kg] as compared to the non-carnitine group [−0.02 (−0.04 to 0.01) kgf/kg]. Multivariable-adjusted regression analysis showed the positive association between the change in KES and the treatment with levocarnitine remained significant after adjustment for the baseline KES and other potential confounders. Thus, treatment with intravenous levocarnitine was independently and positively associated with the change in KES among hemodialysis patients. Further clinical trials are needed to provide more solid evidence. MDPI 2022-01-14 /pmc/articles/PMC8782050/ /pubmed/35057527 http://dx.doi.org/10.3390/nu14020343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsufuji, Shota
Shoji, Tetsuo
Lee, Suhye
Yamaguchi, Masao
Nishimura, Mari
Tsujimoto, Yoshihiro
Nakatani, Shinya
Morioka, Tomoaki
Mori, Katsuhito
Emoto, Masanori
Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title_full Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title_fullStr Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title_full_unstemmed Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title_short Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)
title_sort association between levocarnitine treatment and the change in knee extensor strength in patients undergoing hemodialysis: a post-hoc analysis of the osaka dialysis complication study (odcs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782050/
https://www.ncbi.nlm.nih.gov/pubmed/35057527
http://dx.doi.org/10.3390/nu14020343
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