Disruption of c-MYC Binding and Chromosomal Looping Involving Genetic Variants Associated With Ankylosing Spondylitis Upstream of the RUNX3 Promoter

Background: Ankylosing Spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex aetiology and high heritability, involving more than 100 genetic associations. These include several AS-associated single nucleotide polymorphisms (SNPs) upstream of RUNX3, which encodes the mult...

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Detalles Bibliográficos
Autores principales: Cohen, Carla J., Davidson, Connor, Selmi, Carlo, Bowness, Paul, Knight, Julian C., Wordsworth, B. Paul, Vecellio, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782160/
https://www.ncbi.nlm.nih.gov/pubmed/35069677
http://dx.doi.org/10.3389/fgene.2021.741867

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