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Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey

In preparation for the National Hepatitis C Elimination Program in the country of Georgia, a nationwide household-based hepatitis C virus (HCV) seroprevalence survey was conducted in 2015. Data were used to estimate HCV genotype distribution and better understand potential sex-specific risk factors...

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Autores principales: Baliashvili, Davit, Averhoff, Francisco, Kasradze, Ana, Salyer, Stephanie J., Kuchukhidze, Giorgi, Gamkrelidze, Amiran, Imnadze, Paata, Alkhazashvili, Maia, Chanturia, Gvantsa, Chitadze, Nazibrola, Sukhiashvili, Roena, Blanton, Curtis, Drobeniuc, Jan, Morgan, Juliette, Hagan, Liesl M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782338/
https://www.ncbi.nlm.nih.gov/pubmed/35061841
http://dx.doi.org/10.1371/journal.pone.0262935
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author Baliashvili, Davit
Averhoff, Francisco
Kasradze, Ana
Salyer, Stephanie J.
Kuchukhidze, Giorgi
Gamkrelidze, Amiran
Imnadze, Paata
Alkhazashvili, Maia
Chanturia, Gvantsa
Chitadze, Nazibrola
Sukhiashvili, Roena
Blanton, Curtis
Drobeniuc, Jan
Morgan, Juliette
Hagan, Liesl M.
author_facet Baliashvili, Davit
Averhoff, Francisco
Kasradze, Ana
Salyer, Stephanie J.
Kuchukhidze, Giorgi
Gamkrelidze, Amiran
Imnadze, Paata
Alkhazashvili, Maia
Chanturia, Gvantsa
Chitadze, Nazibrola
Sukhiashvili, Roena
Blanton, Curtis
Drobeniuc, Jan
Morgan, Juliette
Hagan, Liesl M.
author_sort Baliashvili, Davit
collection PubMed
description In preparation for the National Hepatitis C Elimination Program in the country of Georgia, a nationwide household-based hepatitis C virus (HCV) seroprevalence survey was conducted in 2015. Data were used to estimate HCV genotype distribution and better understand potential sex-specific risk factors that contribute to HCV transmission. HCV genotype distribution by sex and reported risk factors were calculated. We used explanatory logistic regression models stratified by sex to identify behavioral and healthcare-related risk factors for HCV seropositivity, and predictive logistic regression models to identify additional variables that could help predict the presence of infection. Factors associated with HCV seropositivity in explanatory models included, among males, history of injection drug use (IDU) (aOR = 22.4, 95% CI = 12.7, 39.8) and receiving a blood transfusion (aOR = 3.6, 95% CI = 1.4, 8.8), and among females, history of receiving a blood transfusion (aOR = 4.0, 95% CI 2.1, 7.7), kidney dialysis (aOR = 7.3 95% CI 1.5, 35.3) and surgery (aOR = 1.9, 95% CI 1.1, 3.2). The male-specific predictive model additionally identified age, urban residence, and history of incarceration as factors predictive of seropositivity and were used to create a male-specific exposure index (Area under the curve [AUC] = 0.84). The female-specific predictive model had insufficient discriminatory performance to support creating an exposure index (AUC = 0.61). The most prevalent HCV genotype (GT) nationally was GT1b (40.5%), followed by GT3 (34.7%) and GT2 (23.6%). Risk factors for HCV seropositivity and distribution of HCV genotypes in Georgia vary substantially by sex. The HCV exposure index developed for males could be used to inform targeted testing programs.
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spelling pubmed-87823382022-01-22 Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey Baliashvili, Davit Averhoff, Francisco Kasradze, Ana Salyer, Stephanie J. Kuchukhidze, Giorgi Gamkrelidze, Amiran Imnadze, Paata Alkhazashvili, Maia Chanturia, Gvantsa Chitadze, Nazibrola Sukhiashvili, Roena Blanton, Curtis Drobeniuc, Jan Morgan, Juliette Hagan, Liesl M. PLoS One Research Article In preparation for the National Hepatitis C Elimination Program in the country of Georgia, a nationwide household-based hepatitis C virus (HCV) seroprevalence survey was conducted in 2015. Data were used to estimate HCV genotype distribution and better understand potential sex-specific risk factors that contribute to HCV transmission. HCV genotype distribution by sex and reported risk factors were calculated. We used explanatory logistic regression models stratified by sex to identify behavioral and healthcare-related risk factors for HCV seropositivity, and predictive logistic regression models to identify additional variables that could help predict the presence of infection. Factors associated with HCV seropositivity in explanatory models included, among males, history of injection drug use (IDU) (aOR = 22.4, 95% CI = 12.7, 39.8) and receiving a blood transfusion (aOR = 3.6, 95% CI = 1.4, 8.8), and among females, history of receiving a blood transfusion (aOR = 4.0, 95% CI 2.1, 7.7), kidney dialysis (aOR = 7.3 95% CI 1.5, 35.3) and surgery (aOR = 1.9, 95% CI 1.1, 3.2). The male-specific predictive model additionally identified age, urban residence, and history of incarceration as factors predictive of seropositivity and were used to create a male-specific exposure index (Area under the curve [AUC] = 0.84). The female-specific predictive model had insufficient discriminatory performance to support creating an exposure index (AUC = 0.61). The most prevalent HCV genotype (GT) nationally was GT1b (40.5%), followed by GT3 (34.7%) and GT2 (23.6%). Risk factors for HCV seropositivity and distribution of HCV genotypes in Georgia vary substantially by sex. The HCV exposure index developed for males could be used to inform targeted testing programs. Public Library of Science 2022-01-21 /pmc/articles/PMC8782338/ /pubmed/35061841 http://dx.doi.org/10.1371/journal.pone.0262935 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Baliashvili, Davit
Averhoff, Francisco
Kasradze, Ana
Salyer, Stephanie J.
Kuchukhidze, Giorgi
Gamkrelidze, Amiran
Imnadze, Paata
Alkhazashvili, Maia
Chanturia, Gvantsa
Chitadze, Nazibrola
Sukhiashvili, Roena
Blanton, Curtis
Drobeniuc, Jan
Morgan, Juliette
Hagan, Liesl M.
Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title_full Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title_fullStr Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title_full_unstemmed Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title_short Risk factors and genotype distribution of hepatitis C virus in Georgia: A nationwide population-based survey
title_sort risk factors and genotype distribution of hepatitis c virus in georgia: a nationwide population-based survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782338/
https://www.ncbi.nlm.nih.gov/pubmed/35061841
http://dx.doi.org/10.1371/journal.pone.0262935
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