Cargando…

Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment

The ability to accurately complete goal-directed actions, such as reaching for a glass of water, requires coordination between sensory, cognitive and motor systems. When these systems are impaired, like in people with multiple sclerosis (PwMS), deficits in movement arise. To date, the characterizati...

Descripción completa

Detalles Bibliográficos
Autores principales: Wijeyaratnam, Darrin O., Edwards, Thomas, Pilutti, Lara A., Cressman, Erin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782348/
https://www.ncbi.nlm.nih.gov/pubmed/35061785
http://dx.doi.org/10.1371/journal.pone.0262480
_version_ 1784638294347218944
author Wijeyaratnam, Darrin O.
Edwards, Thomas
Pilutti, Lara A.
Cressman, Erin K.
author_facet Wijeyaratnam, Darrin O.
Edwards, Thomas
Pilutti, Lara A.
Cressman, Erin K.
author_sort Wijeyaratnam, Darrin O.
collection PubMed
description The ability to accurately complete goal-directed actions, such as reaching for a glass of water, requires coordination between sensory, cognitive and motor systems. When these systems are impaired, like in people with multiple sclerosis (PwMS), deficits in movement arise. To date, the characterization of upper limb performance in PwMS has typically been limited to results attained from self-reported questionnaires or clinical tools. Our aim was to characterize visually guided reaching performance in PwMS. Thirty-six participants (12 PwMS who reported upper limb impairment (MS-R), 12 PwMS who reported not experiencing upper limb impairment (MS-NR), and 12 age- and sex-matched control participants without MS (CTL)) reached to 8 targets in a virtual environment while seeing a visual representation of their hand in the form of a cursor on the screen. Reaches were completed with both the dominant and non-dominant hands. All participants were able to complete the visually guided reaching task, such that their hand landed on the target. However, PwMS showed noticeably more atypical reaching profiles when compared to control participants. In accordance with these observations, analyses of reaching performance revealed that the MS-R group was more variable with respect to the time it took to initiate and complete their movements compared to the CTL group. While performance of the MS-NR group did not differ significantly from either the CTL or MS-R groups, individuals in the MS-NR group were less consistent in their performance compared to the CTL group. Together these findings suggest that PwMS with and without self-reported upper limb impairment have deficits in the planning and/or control of their movements. We further argue that deficits observed during movement in PwMS who report upper limb impairment may arise due to participants compensating for impaired movement planning processes.
format Online
Article
Text
id pubmed-8782348
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-87823482022-01-22 Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment Wijeyaratnam, Darrin O. Edwards, Thomas Pilutti, Lara A. Cressman, Erin K. PLoS One Research Article The ability to accurately complete goal-directed actions, such as reaching for a glass of water, requires coordination between sensory, cognitive and motor systems. When these systems are impaired, like in people with multiple sclerosis (PwMS), deficits in movement arise. To date, the characterization of upper limb performance in PwMS has typically been limited to results attained from self-reported questionnaires or clinical tools. Our aim was to characterize visually guided reaching performance in PwMS. Thirty-six participants (12 PwMS who reported upper limb impairment (MS-R), 12 PwMS who reported not experiencing upper limb impairment (MS-NR), and 12 age- and sex-matched control participants without MS (CTL)) reached to 8 targets in a virtual environment while seeing a visual representation of their hand in the form of a cursor on the screen. Reaches were completed with both the dominant and non-dominant hands. All participants were able to complete the visually guided reaching task, such that their hand landed on the target. However, PwMS showed noticeably more atypical reaching profiles when compared to control participants. In accordance with these observations, analyses of reaching performance revealed that the MS-R group was more variable with respect to the time it took to initiate and complete their movements compared to the CTL group. While performance of the MS-NR group did not differ significantly from either the CTL or MS-R groups, individuals in the MS-NR group were less consistent in their performance compared to the CTL group. Together these findings suggest that PwMS with and without self-reported upper limb impairment have deficits in the planning and/or control of their movements. We further argue that deficits observed during movement in PwMS who report upper limb impairment may arise due to participants compensating for impaired movement planning processes. Public Library of Science 2022-01-21 /pmc/articles/PMC8782348/ /pubmed/35061785 http://dx.doi.org/10.1371/journal.pone.0262480 Text en © 2022 Wijeyaratnam et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wijeyaratnam, Darrin O.
Edwards, Thomas
Pilutti, Lara A.
Cressman, Erin K.
Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title_full Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title_fullStr Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title_full_unstemmed Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title_short Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
title_sort assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782348/
https://www.ncbi.nlm.nih.gov/pubmed/35061785
http://dx.doi.org/10.1371/journal.pone.0262480
work_keys_str_mv AT wijeyaratnamdarrino assessingvisuallyguidedreachinginpeoplewithmultiplesclerosiswithandwithoutselfreportedupperlimbimpairment
AT edwardsthomas assessingvisuallyguidedreachinginpeoplewithmultiplesclerosiswithandwithoutselfreportedupperlimbimpairment
AT piluttilaraa assessingvisuallyguidedreachinginpeoplewithmultiplesclerosiswithandwithoutselfreportedupperlimbimpairment
AT cressmanerink assessingvisuallyguidedreachinginpeoplewithmultiplesclerosiswithandwithoutselfreportedupperlimbimpairment