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Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders
INTRODUCTION: Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782350/ https://www.ncbi.nlm.nih.gov/pubmed/35061846 http://dx.doi.org/10.1371/journal.pone.0262903 |
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author | Mbaga, Donatien Serge Kenmoe, Sebastien Kengne-Ndé, Cyprien Ebogo-Belobo, Jean Thierry Mahamat, Gadji Foe-Essomba, Joseph Rodrigue Amougou-Atsama, Marie Tchatchouang, Serges Nyebe, Inès Feudjio, Alfloditte Flore Kame-Ngasse, Ginette Irma Magoudjou-Pekam, Jeannette Nina Fokou, Lorraine K. M. Meta-Djomsi, Dowbiss Maïdadi-Foudi, Martin Touangnou-Chamda, Sabine Aimee Daha-Tchoffo, Audrey Gaelle Selly-Ngaloumo, Abdel Aziz Nayang-Mundo, Rachel Audrey Yéngué, Jacqueline Félicité Taya-Fokou, Jean Bosco Kenfack-Momo, Raoul Atembeh Noura, Efietngab Demeni Emoh, Cynthia Paola Tazokong, Hervé Raoul Bowo-Ngandji, Arnol Sake, Carole Stéphanie Atenguena Okobalemba, Etienne Njiki Bikoi, Jacky Njouom, Richard Riwom Essama, Sara Honorine |
author_facet | Mbaga, Donatien Serge Kenmoe, Sebastien Kengne-Ndé, Cyprien Ebogo-Belobo, Jean Thierry Mahamat, Gadji Foe-Essomba, Joseph Rodrigue Amougou-Atsama, Marie Tchatchouang, Serges Nyebe, Inès Feudjio, Alfloditte Flore Kame-Ngasse, Ginette Irma Magoudjou-Pekam, Jeannette Nina Fokou, Lorraine K. M. Meta-Djomsi, Dowbiss Maïdadi-Foudi, Martin Touangnou-Chamda, Sabine Aimee Daha-Tchoffo, Audrey Gaelle Selly-Ngaloumo, Abdel Aziz Nayang-Mundo, Rachel Audrey Yéngué, Jacqueline Félicité Taya-Fokou, Jean Bosco Kenfack-Momo, Raoul Atembeh Noura, Efietngab Demeni Emoh, Cynthia Paola Tazokong, Hervé Raoul Bowo-Ngandji, Arnol Sake, Carole Stéphanie Atenguena Okobalemba, Etienne Njiki Bikoi, Jacky Njouom, Richard Riwom Essama, Sara Honorine |
author_sort | Mbaga, Donatien Serge |
collection | PubMed |
description | INTRODUCTION: Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa. METHODS: Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses. RESULTS: A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7–105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2–15.6]) and DNA (OR = 8.9; 95% CI = [5.9–13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3–14.0]) and RNA (OR = 16.5; 95% CI = [7.8–34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9–112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3–387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0–13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6–10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4–13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results. CONCLUSIONS: In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed. |
format | Online Article Text |
id | pubmed-8782350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-87823502022-01-22 Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders Mbaga, Donatien Serge Kenmoe, Sebastien Kengne-Ndé, Cyprien Ebogo-Belobo, Jean Thierry Mahamat, Gadji Foe-Essomba, Joseph Rodrigue Amougou-Atsama, Marie Tchatchouang, Serges Nyebe, Inès Feudjio, Alfloditte Flore Kame-Ngasse, Ginette Irma Magoudjou-Pekam, Jeannette Nina Fokou, Lorraine K. M. Meta-Djomsi, Dowbiss Maïdadi-Foudi, Martin Touangnou-Chamda, Sabine Aimee Daha-Tchoffo, Audrey Gaelle Selly-Ngaloumo, Abdel Aziz Nayang-Mundo, Rachel Audrey Yéngué, Jacqueline Félicité Taya-Fokou, Jean Bosco Kenfack-Momo, Raoul Atembeh Noura, Efietngab Demeni Emoh, Cynthia Paola Tazokong, Hervé Raoul Bowo-Ngandji, Arnol Sake, Carole Stéphanie Atenguena Okobalemba, Etienne Njiki Bikoi, Jacky Njouom, Richard Riwom Essama, Sara Honorine PLoS One Research Article INTRODUCTION: Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa. METHODS: Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses. RESULTS: A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7–105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2–15.6]) and DNA (OR = 8.9; 95% CI = [5.9–13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3–14.0]) and RNA (OR = 16.5; 95% CI = [7.8–34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9–112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3–387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0–13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6–10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4–13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results. CONCLUSIONS: In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed. Public Library of Science 2022-01-21 /pmc/articles/PMC8782350/ /pubmed/35061846 http://dx.doi.org/10.1371/journal.pone.0262903 Text en © 2022 Mbaga et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mbaga, Donatien Serge Kenmoe, Sebastien Kengne-Ndé, Cyprien Ebogo-Belobo, Jean Thierry Mahamat, Gadji Foe-Essomba, Joseph Rodrigue Amougou-Atsama, Marie Tchatchouang, Serges Nyebe, Inès Feudjio, Alfloditte Flore Kame-Ngasse, Ginette Irma Magoudjou-Pekam, Jeannette Nina Fokou, Lorraine K. M. Meta-Djomsi, Dowbiss Maïdadi-Foudi, Martin Touangnou-Chamda, Sabine Aimee Daha-Tchoffo, Audrey Gaelle Selly-Ngaloumo, Abdel Aziz Nayang-Mundo, Rachel Audrey Yéngué, Jacqueline Félicité Taya-Fokou, Jean Bosco Kenfack-Momo, Raoul Atembeh Noura, Efietngab Demeni Emoh, Cynthia Paola Tazokong, Hervé Raoul Bowo-Ngandji, Arnol Sake, Carole Stéphanie Atenguena Okobalemba, Etienne Njiki Bikoi, Jacky Njouom, Richard Riwom Essama, Sara Honorine Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title_full | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title_fullStr | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title_full_unstemmed | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title_short | Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders |
title_sort | hepatitis b, c and d virus infections and risk of hepatocellular carcinoma in africa: a meta-analysis including sensitivity analyses for studies comparable for confounders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782350/ https://www.ncbi.nlm.nih.gov/pubmed/35061846 http://dx.doi.org/10.1371/journal.pone.0262903 |
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