Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Cancer cells voraciously consume nutrients to support their growth, exposing metabolic vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improves sorafenib efficacy and acts synergistic...

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Detalles Bibliográficos
Autores principales: Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R., Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J. A., Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J. R., Huch, Meritxell, Malli, Roland, Prokesch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782451/
https://www.ncbi.nlm.nih.gov/pubmed/35061544
http://dx.doi.org/10.1126/sciadv.abh2635

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