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Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo

Although atherosclerosis preferentially develops at arterial curvatures and bifurcations where disturbed flow (DF) activates endothelium, therapies targeting flow-dependent mechanosensing pathways in the vasculature are unavailable. Here, we provided experimental evidence demonstrating a previously...

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Detalles Bibliográficos
Autores principales:	Yeh, Chih-Fan, Cheng, Shih-Hsin, Lin, Yu-Shan, Shentu, Tzu-Pin, Huang, Ru-Ting, Zhu, Jiayu, Chen, Yen-Ting, Kumar, Sandeep, Lin, Mao-Shin, Kao, Hsien-Li, Huang, Po-Hsun, Roselló-Sastre, Esther, Garcia, Francisca, Jo, Hanjoong, Fang, Yun, Yang, Kai-Chien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782452/ https://www.ncbi.nlm.nih.gov/pubmed/35061532 http://dx.doi.org/10.1126/sciadv.abl8096

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