Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

BACKGROUND: Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. We hypothesized that IFIH1 rs199076 variants would modulate host response and outcome after severe COVID-19. METHODS: Patients admitted to an intensive care unit (ICU) with conf...

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Detalles Bibliográficos
Autores principales: Amado-Rodríguez, Laura, Salgado del Riego, Estefania, Gomez de Ona, Juan, López Alonso, Inés, Gil-Pena, Helena, López-Martínez, Cecilia, Martín-Vicente, Paula, Lopez-Vazquez, Antonio, Gonzalez Lopez, Adrian, Cuesta-Llavona, Elias, Rodriguez-Garcia, Raquel, Boga, Jose Antonio, Elena alvarez-Arguelles, Marta, Mayordomo-Colunga, Juan, Vidal-Castineira, Jose Ramon, Crespo, Irene, Fernandez, Margarita, Criado, Loreto, Salvadores, Victoria, Jimeno-Demuth, Francisco Jose, Blanch, Lluis, Prieto, Belen, Fernandez-Fernandez, Alejandra, Lopez-Larrea, Carlos, Coto, Eliecer, Albaiceta, Guillermo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782569/
https://www.ncbi.nlm.nih.gov/pubmed/35060899
http://dx.doi.org/10.7554/eLife.73012

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