Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study

BACKGROUND: In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection. METHODS: Applying the blood transcriptional module (...

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Detalles Bibliográficos
Autores principales: Moncunill, Gemma, Carnes, Jason, Chad Young, William, Carpp, Lindsay, De Rosa, Stephen, Campo, Joseph J, Nhabomba, Augusto, Mpina, Maxmillian, Jairoce, Chenjerai, Finak, Greg, Haas, Paige, Muriel, Carl, Van, Phu, Sanz, Héctor, Dutta, Sheetij, Mordmüller, Benjamin, Agnandji, Selidji T, Díez-Padrisa, Núria, Williams, Nana Aba, Aponte, John J, Valim, Clarissa, Neafsey, Daniel E, Daubenberger, Claudia, McElrath, M Juliana, Dobaño, Carlota, Stuart, Ken, Gottardo, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782572/
https://www.ncbi.nlm.nih.gov/pubmed/35060479
http://dx.doi.org/10.7554/eLife.70393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782572/
https://www.ncbi.nlm.nih.gov/pubmed/35060479
http://dx.doi.org/10.7554/eLife.70393

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