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Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications
Background: We assessed the relationship between preoperative prognostic nutritional index (PNI) and short- and long-term outcomes among gastric cancer patients because the clinical significance of PNI in these patients remains controversial. Materials and Methods: We retrospectively reviewed the me...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782615/ https://www.ncbi.nlm.nih.gov/pubmed/35079325 http://dx.doi.org/10.18632/oncotarget.28179 |
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author | Hirahara, Noriyuki Matsubara, Takeshi Kaji, Shunsuke Uchida, Yuki Hyakudomi, Ryoji Yamamoto, Tetsu Takai, Kiyoe Sasaki, Yohei Kawakami, Koki Tajima, Yoshitsugu |
author_facet | Hirahara, Noriyuki Matsubara, Takeshi Kaji, Shunsuke Uchida, Yuki Hyakudomi, Ryoji Yamamoto, Tetsu Takai, Kiyoe Sasaki, Yohei Kawakami, Koki Tajima, Yoshitsugu |
author_sort | Hirahara, Noriyuki |
collection | PubMed |
description | Background: We assessed the relationship between preoperative prognostic nutritional index (PNI) and short- and long-term outcomes among gastric cancer patients because the clinical significance of PNI in these patients remains controversial. Materials and Methods: We retrospectively reviewed the medical records of 434 consecutive patients who underwent curative laparoscopic gastrectomy for gastric cancer. Results: Patients with postoperative complications had a significantly poorer overall survival (OS) than those without. On multivariate analyses, postoperative complications were independently associated with PNI value and operative procedure type. In the low PNI group (n = 118), those with postoperative complications experienced significantly poorer OS than those without complications. Among the low PNI group with pTNM stage I and II disease, those with postoperative complications experienced significantly worse OS than those without complications. However, among the high PNI group and patients with stage II and III disease in the low PNI group, OS was similar with respect to postoperative complications. Conclusions: The present study confirmed that long-term prognosis was unaffected by postoperative complications in well-nourished gastric cancer patients. In addition, preoperative nutritional status and postoperative complications, may be crucial in determining the prognosis of gastric cancer, especially in early-stage cancer. |
format | Online Article Text |
id | pubmed-8782615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-87826152022-01-24 Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications Hirahara, Noriyuki Matsubara, Takeshi Kaji, Shunsuke Uchida, Yuki Hyakudomi, Ryoji Yamamoto, Tetsu Takai, Kiyoe Sasaki, Yohei Kawakami, Koki Tajima, Yoshitsugu Oncotarget Research Paper Background: We assessed the relationship between preoperative prognostic nutritional index (PNI) and short- and long-term outcomes among gastric cancer patients because the clinical significance of PNI in these patients remains controversial. Materials and Methods: We retrospectively reviewed the medical records of 434 consecutive patients who underwent curative laparoscopic gastrectomy for gastric cancer. Results: Patients with postoperative complications had a significantly poorer overall survival (OS) than those without. On multivariate analyses, postoperative complications were independently associated with PNI value and operative procedure type. In the low PNI group (n = 118), those with postoperative complications experienced significantly poorer OS than those without complications. Among the low PNI group with pTNM stage I and II disease, those with postoperative complications experienced significantly worse OS than those without complications. However, among the high PNI group and patients with stage II and III disease in the low PNI group, OS was similar with respect to postoperative complications. Conclusions: The present study confirmed that long-term prognosis was unaffected by postoperative complications in well-nourished gastric cancer patients. In addition, preoperative nutritional status and postoperative complications, may be crucial in determining the prognosis of gastric cancer, especially in early-stage cancer. Impact Journals LLC 2022-01-21 /pmc/articles/PMC8782615/ /pubmed/35079325 http://dx.doi.org/10.18632/oncotarget.28179 Text en Copyright: © 2022 Hirahara et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hirahara, Noriyuki Matsubara, Takeshi Kaji, Shunsuke Uchida, Yuki Hyakudomi, Ryoji Yamamoto, Tetsu Takai, Kiyoe Sasaki, Yohei Kawakami, Koki Tajima, Yoshitsugu Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title | Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title_full | Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title_fullStr | Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title_full_unstemmed | Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title_short | Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
title_sort | influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782615/ https://www.ncbi.nlm.nih.gov/pubmed/35079325 http://dx.doi.org/10.18632/oncotarget.28179 |
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