Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern

BACKGROUND: The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S protein raised concern about activity of current vaccines and therapeutic antibodies. Independent studies have shown that mutant var...

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Detalles Bibliográficos
Autores principales: Kovacech, Branislav, Fialova, Lubica, Filipcik, Peter, Skrabana, Rostislav, Zilkova, Monika, Paulenka-Ivanovova, Natalia, Kovac, Andrej, Palova, Denisa, Rolkova, Gabriela Paulikova, Tomkova, Katarina, Csokova, Natalia Turic, Markova, Karina, Skrabanova, Michaela, Sinska, Kristina, Basheer, Neha, Majerova, Petra, Hanes, Jozef, Parrak, Vojtech, Prcina, Michal, Cehlar, Ondrej, Cente, Martin, Piestansky, Juraj, Fresser, Michal, Novak, Michal, Slavikova, Monika, Borsova, Kristina, Cabanova, Viktoria, Brejova, Bronislava, Vinař, Tomas, Nosek, Jozef, Klempa, Boris, Eyer, Ludek, Hönig, Vaclav, Palus, Martin, Ruzek, Daniel, Vyhlidalova, Tereza, Strakova, Petra, Mrazkova, Blanka, Zudova, Dagmar, Koubkova, Gizela, Novosadova, Vendula, Prochazka, Jan, Sedlacek, Radislav, Zilka, Norbert, Kontsekova, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782626/
https://www.ncbi.nlm.nih.gov/pubmed/35078012
http://dx.doi.org/10.1016/j.ebiom.2022.103818

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