Cargando…

Production and Characterization of RNA Aptamers Specific for Amyloid Fibril Epitopes

One of the most fascinating features of amyloid fibrils is their generic cross-β architecture that can be formed from many different and completely unrelated proteins. Nonetheless, amyloid fibrils with diverse structural and phenotypic properties can form, both in vivo and in vitro, from the same pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bunka, David H.J., Mantle, Benjamin J., Morten, Isobel J., Tennent, Glenys A., Radford, Sheena E., Stockley, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782670/ https://www.ncbi.nlm.nih.gov/pubmed/17878167 http://dx.doi.org/10.1074/jbc.M703679200

Ejemplares similares

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Fibril Fragmentation Enhances Amyloid Cytotoxicity
por: Xue, Wei-Feng, et al.
Publicado: (2009)

Stacked Sets of Parallel, In-register β-Strands of β(2)-Microglobulin in Amyloid Fibrils Revealed by Site-directed Spin Labeling and Chemical Labeling
por: Ladner, Carol L., et al.
Publicado: (2010)

Comparisons with Amyloid-β Reveal an Aspartate Residue That Stabilizes Fibrils of the Aortic Amyloid Peptide Medin
por: Davies, Hannah A., et al.
Publicado: (2015)

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?
por: Smith, Hugh I., et al.
Publicado: (2020)

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER
por: Ano Bom, Ana P. D., et al.
Publicado: (2012)

A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies
por: Peeß, Carmen, et al.
Publicado: (2019)

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins
por: Martin, Esther M., et al.
Publicado: (2018)

Stabilization, Characterization, and Selective Removal of Cystatin C Amyloid Oligomers
por: Östner, Gustav, et al.
Publicado: (2013)

Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability
por: Pradhan, Tejaswini, et al.
Publicado: (2021)

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
por: Alexandrov, Ilya M., et al.
Publicado: (2008)

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17
por: Dean, Dexter N., et al.
Publicado: (2020)

Structural Analysis of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Intracellular Domain Reveals a Conserved Interaction Epitope
por: Mayer, Christina, et al.
Publicado: (2012)

Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
por: de Taeye, Steven W., et al.
Publicado: (2019)

Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations
por: Meyer, Virginia, et al.
Publicado: (2016)

Structural basis for the specificity of renin-mediated angiotensinogen cleavage
por: Carrell, Robin W., et al.
Publicado: (2019)

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells
por: Melo dos Santos, Nataly, et al.
Publicado: (2019)

Understanding How Noncatalytic Carbohydrate Binding Modules Can Display Specificity for Xyloglucan
por: Luís, Ana S., et al.
Publicado: (2013)

Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity
por: Chinthalapudi, Krishna, et al.
Publicado: (2011)

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
por: Dagbay, Kevin B., et al.
Publicado: (2020)

A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore
por: Streit, Anne K., et al.
Publicado: (2011)

Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus
por: Grigg, Jason C., et al.
Publicado: (2010)

Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity
por: Rutsdottir, Gudrun, et al.
Publicado: (2017)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK
por: Dias, Marcio V. B., et al.
Publicado: (2010)

Structure-specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones
por: Marcianò, Gabriele, et al.
Publicado: (2018)

Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica
por: Stern, Ana Laura, et al.
Publicado: (2018)

3′-Phosphoadenosine 5′-Phosphosulfate (PAPS) Synthases, Naturally Fragile Enzymes Specifically Stabilized by Nucleotide Binding
por: van den Boom, Johannes, et al.
Publicado: (2012)

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain
por: Hexnerová, Rozálie, et al.
Publicado: (2016)

cpSRP43 Is a Novel Chaperone Specific for Light-harvesting Chlorophyll a,b-binding Proteins
por: Falk, Sebastian, et al.
Publicado: (2010)

Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1(D2): RECOGNITION AND SPECIFICITY
por: Iyer, Shalini, et al.
Publicado: (2010)

Novel UDP-GalNAc Derivative Structures Provide Insight into the Donor Specificity of Human Blood Group Glycosyltransferase
por: Wagner, Gerd K., et al.
Publicado: (2015)

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery
por: Schelpe, Julien, et al.
Publicado: (2016)

Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR
por: Owen, C. David, et al.
Publicado: (2015)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

Structure and Interactions of Myosin-binding Protein C Domain C0: CARDIAC-SPECIFIC REGULATION OF MYOSIN AT ITS NECK?
por: Ratti, Joyce, et al.
Publicado: (2011)

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces
por: Moore, Benjamin, et al.
Publicado: (2011)

Structure of the Trypanosoma brucei p22 Protein, a Cytochrome Oxidase Subunit II-specific RNA-editing Accessory Factor
por: Sprehe, Mareen, et al.
Publicado: (2010)

Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
por: Noda, Nobuo N., et al.
Publicado: (2012)

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses
por: Macháčková, Kateřina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m16cf74gjlidj8cd4r7iqcuhe3