FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees

Mutations in FUS and TBK1 often cause aggressive early-onset amyotrophic lateral sclerosis (ALS) or a late-onset ALS and/or frontotemporal dementia (FTD) phenotype, respectively. Co-occurrence of mutations in two or more Mendelian ALS/FTD genes has been repeatedly reported. However, little is known...

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Detalles Bibliográficos
Autores principales: Brenner, David, Müller, Kathrin, Lattante, Serena, Yilmaz, Rüstem, Knehr, Antje, Freischmidt, Axel, Ludolph, Albert C., Andersen, Peter M., Weishaupt, Jochen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782814/
https://www.ncbi.nlm.nih.gov/pubmed/34518945
http://dx.doi.org/10.1007/s10048-021-00671-4

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